TY - JOUR
T1 - Fatal splenic rupture in a pregnant woman with hemoglobin C/β-thalassemia and myeloid metaplasia
AU - Boldorini, Renzo
AU - Bozzola, Cristina
AU - Gallarotti, Eleonora
AU - Ribaldone, Raffaella
PY - 2006/8
Y1 - 2006/8
N2 - Splenic rupture with intraperitoneal hemorrhage is a fatal condition that is rarely encountered during the third trimester of pregnancy; its pathogenetic mechanisms and causes are largely unknown. We report a case of splenic rupture in a pregnant woman that caused the death of the mother and child. The patient was a carrier of double heterozygosis for hemoglobin C/β-thalassemia. Spleen and liver enlargement due to extramedullary hematopoiesis was found at autopsy. Our data suggest that rare and hidden hematologic disorders should be considered as possible causes of splenic enlargement and rupture during pregnancy.
AB - Splenic rupture with intraperitoneal hemorrhage is a fatal condition that is rarely encountered during the third trimester of pregnancy; its pathogenetic mechanisms and causes are largely unknown. We report a case of splenic rupture in a pregnant woman that caused the death of the mother and child. The patient was a carrier of double heterozygosis for hemoglobin C/β-thalassemia. Spleen and liver enlargement due to extramedullary hematopoiesis was found at autopsy. Our data suggest that rare and hidden hematologic disorders should be considered as possible causes of splenic enlargement and rupture during pregnancy.
UR - https://www.scopus.com/pages/publications/33746667815
U2 - 10.5858/2006-130-1231-fsriap
DO - 10.5858/2006-130-1231-fsriap
M3 - Article
SN - 0003-9985
VL - 130
SP - 1231
EP - 1232
JO - Archives of Pathology and Laboratory Medicine
JF - Archives of Pathology and Laboratory Medicine
IS - 8
ER -