TY - JOUR
T1 - Fat injection for cases of severe burn outcomes
T2 - A new perspective of scar remodeling and reduction
AU - Klinger, M.
AU - Marazzi, M.
AU - Vigo, D.
AU - Torre, M.
PY - 2008/5
Y1 - 2008/5
N2 - Background: Despite civilization and progress, burns occur frequently in the world. Remarkable discoveries of wound healing mechanisms have been reported. On the other hand, long-term outcomes from burn injuries represent a barrier to improvement of patients' social, functional, and psychological condition. Lipofilling, described since the 1980s, currently is used for several clinical applications. This study aimed to verify whether lipofilling could ameliorate scar remodeling in three clinical cases. Methods: Three adult patients with hemifacial hypertrophic scars and keloids resulting from severe burns 2 to 13 years previously were selected. The patients were treated by injection of adipose tissue harvested from abdominal subcutaneous fat and processed according to Coleman's technique. Two injections (with a 13-month interval between) were administered at the dermohypodermal junction. Histologic examination of scar tissue punch biopsies (hematoxylin-eosin staining) before and after the treatment was performed as well as magnetic resonance scan with contrast. Results: The clinical appearance and subjective patient feelings after a 6-month follow-up period suggest considerable improvement in the mimic features, skin texture, and thickness. Histologic examination shows patterns of new collagen deposition, local hypervascularity, and dermal hyperplasia in the context of new tissue, with high correspondence to the original. Conclusions: The preliminary results show that lipofilling improves scar quality and suggest a tissue regeneration enhancing process.
AB - Background: Despite civilization and progress, burns occur frequently in the world. Remarkable discoveries of wound healing mechanisms have been reported. On the other hand, long-term outcomes from burn injuries represent a barrier to improvement of patients' social, functional, and psychological condition. Lipofilling, described since the 1980s, currently is used for several clinical applications. This study aimed to verify whether lipofilling could ameliorate scar remodeling in three clinical cases. Methods: Three adult patients with hemifacial hypertrophic scars and keloids resulting from severe burns 2 to 13 years previously were selected. The patients were treated by injection of adipose tissue harvested from abdominal subcutaneous fat and processed according to Coleman's technique. Two injections (with a 13-month interval between) were administered at the dermohypodermal junction. Histologic examination of scar tissue punch biopsies (hematoxylin-eosin staining) before and after the treatment was performed as well as magnetic resonance scan with contrast. Results: The clinical appearance and subjective patient feelings after a 6-month follow-up period suggest considerable improvement in the mimic features, skin texture, and thickness. Histologic examination shows patterns of new collagen deposition, local hypervascularity, and dermal hyperplasia in the context of new tissue, with high correspondence to the original. Conclusions: The preliminary results show that lipofilling improves scar quality and suggest a tissue regeneration enhancing process.
KW - Adipose cell
KW - Burn
KW - Liposuction
KW - Scar
KW - Stem cell
UR - http://www.scopus.com/inward/record.url?scp=44649172470&partnerID=8YFLogxK
U2 - 10.1007/s00266-008-9122-1
DO - 10.1007/s00266-008-9122-1
M3 - Article
SN - 0364-216X
VL - 32
SP - 465
EP - 469
JO - Aesthetic Plastic Surgery
JF - Aesthetic Plastic Surgery
IS - 3
ER -