Fast and easy access to efﬁcient bifunctional chelators for MRI applications

GIUSEPPE GUGLIOTTA; Mauro BOTTA; Giovanni Battista GIOVENZANA; LORENZO TEI

doi:10.1016/j.bmcl.2009.05.024

Fast and easy access to efﬁcient bifunctional chelators for MRI applications

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The Gd^III complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported.

Lingua originale	Inglese
pagine (da-a)	3442-3444
Numero di pagine	3
Rivista	Bioorganic and Medicinal Chemistry Letters
Volume	19
DOI	https://doi.org/10.1016/j.bmcl.2009.05.024
Stato di pubblicazione	Pubblicato - 2009

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10.1016/j.bmcl.2009.05.024

http://hdl.handle.net/11579/32852

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title = "Fast and easy access to efﬁcient bifunctional chelators for MRI applications",

abstract = "Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The GdIII complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported.",

author = "GIUSEPPE GUGLIOTTA and Mauro BOTTA and GIOVENZANA, \{Giovanni Battista\} and LORENZO TEI",

note = "Funding Information: We thank the support of the Regione Piemonte (Ricerca Sanitaria Finalizzata 2007). CIRCMSB and EC COST Action D38 are also acknowledged. ",

year = "2009",

doi = "10.1016/j.bmcl.2009.05.024",

language = "English",

volume = "19",

pages = "3442--3444",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd.",

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T1 - Fast and easy access to efﬁcient bifunctional chelators for MRI applications

AU - GUGLIOTTA, GIUSEPPE

AU - BOTTA, Mauro

AU - GIOVENZANA, Giovanni Battista

AU - TEI, LORENZO

N1 - Funding Information: We thank the support of the Regione Piemonte (Ricerca Sanitaria Finalizzata 2007). CIRCMSB and EC COST Action D38 are also acknowledged.

PY - 2009

Y1 - 2009

N2 - Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The GdIII complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported.

AB - Novel bifunctional agents based on the AAZTA (6-amino-6-methylperhydro-1,4-diazepinetetraacetic acid) structure with hydroxyl, carboxyl and chloro functional groups were prepared. The GdIII complexes show optimal magnetic properties making them very good candidates for conjugation to biomolecules for molecular imaging applications. An example of conjugation to a bile acid derivative is also reported.

UR - https://iris.uniupo.it/handle/11579/32852

U2 - 10.1016/j.bmcl.2009.05.024

DO - 10.1016/j.bmcl.2009.05.024

M3 - Article

SN - 0960-894X

VL - 19

SP - 3442

EP - 3444

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

ER -

Fast and easy access to efﬁcient bifunctional chelators for MRI applications

Abstract

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