TY - JOUR
T1 - Family History in Parkinson's Disease
T2 - A National Cross-Sectional Study
AU - Italian Study Group on Family History in PD
AU - Arienti, Federica
AU - Casazza, Giovanni
AU - Franco, Giulia
AU - Lazzeri, Giulia
AU - Monfrini, Edoardo
AU - Di Maio, Alessandro
AU - Erro, Roberto
AU - Barone, Paolo
AU - Tamma, Filippo
AU - Caputo, Elena
AU - Volontè, Maria Antonietta
AU - Cacciaguerra, Laura
AU - Pilotto, Andrea
AU - Padovani, Alessandro
AU - Comi, Cristoforo
AU - Magistrelli, Luca
AU - Valzania, Franco
AU - Cavallieri, Francesco
AU - Avanzino, Laura
AU - Marchese, Roberta
AU - Sensi, Mariachiara
AU - Carroli, Giorgia
AU - Eleopra, Roberto
AU - Cilia, Roberto
AU - Spagnolo, Francesca
AU - Tessitore, Alessandro
AU - De Micco, Rosa
AU - Ceravolo, Roberto
AU - Palermo, Giovanni
AU - Malaguti, Maria Chiara
AU - Lopiano, Leonardo
AU - Tocco, Pierluigi
AU - Sorbera, Chiara
AU - Tinazzi, Michele
AU - Ciammola, Andrea
AU - Ottaviani, Donatella
AU - Valente, Enza Maria
AU - Albanese, Alberto
AU - Blandini, Fabio
AU - Canesi, Margherita
AU - Antonini, Angelo
AU - Carecchio, Miryam
AU - Fetoni, Vincenza
AU - Colosimo, Carlo
AU - Volpe, Daniele
AU - Tambasco, Nicola
AU - Cossu, Giovanni
AU - Zappia, Mario
AU - Di Fonzo, Alessio
N1 - Publisher Copyright:
© 2024 The Author(s). Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
PY - 2024/11
Y1 - 2024/11
N2 - Background: Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect. Objectives: We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD). Methods: A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected. Results: Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group. Conclusions: fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.
AB - Background: Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect. Objectives: We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD). Methods: A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected. Results: Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group. Conclusions: fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.
KW - bipolar disorder
KW - cognitive impairment
KW - depression
KW - familial and sporadic Parkinson's disease
KW - family history
KW - hyposmia
UR - http://www.scopus.com/inward/record.url?scp=85204022985&partnerID=8YFLogxK
U2 - 10.1002/mdc3.14206
DO - 10.1002/mdc3.14206
M3 - Article
SN - 2330-1619
VL - 11
SP - 1434
EP - 1440
JO - Movement Disorders Clinical Practice
JF - Movement Disorders Clinical Practice
IS - 11
ER -