Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

Clara Guaschino; Federica Esposito; Giuseppe Liberatore; Bruno Colombo; Pietro Annovazzi; Emanuele D'Amico; Paola Cavalla; Elisabetta Capello; Ruggero Capra; Daniela Galimberti; Gioacchino Tedeschi; Luigi Grimaldi; Maurizio Leone; Sandra D'Alfonso; Vittorio Martinelli; Giancarlo Comi; Filippo Martinelli-Boneschi

doi:10.1007/s10072-014-1650-7

Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

Clara Guaschino, Federica Esposito, Giuseppe Liberatore, Bruno Colombo, Pietro Annovazzi, Emanuele D'Amico, Paola Cavalla, Elisabetta Capello, Ruggero Capra, Daniela Galimberti, Gioacchino Tedeschi, Luigi Grimaldi, Maurizio Leone, Sandra D'Alfonso, Vittorio Martinelli, Giancarlo Comi, Filippo Martinelli-Boneschi

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.

Lingua originale	Inglese
pagine (da-a)	789-791
Numero di pagine	3
Rivista	Neurological Sciences
Volume	35
Numero di pubblicazione	5
DOI	https://doi.org/10.1007/s10072-014-1650-7
Stato di pubblicazione	Pubblicato - mag 2014

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Guaschino, C., Esposito, F., Liberatore, G., Colombo, B., Annovazzi, P., D'Amico, E., Cavalla, P., Capello, E., Capra, R., Galimberti, D., Tedeschi, G., Grimaldi, L., Leone, M., D'Alfonso, S., Martinelli, V., Comi, G., & Martinelli-Boneschi, F. (2014). Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis. Neurological Sciences, 35(5), 789-791. https://doi.org/10.1007/s10072-014-1650-7

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title = "Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis",

abstract = "Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.",

keywords = "Multiple sclerosis, Progressive, Recurrence risk, Relapsing-remitting",

author = "Clara Guaschino and Federica Esposito and Giuseppe Liberatore and Bruno Colombo and Pietro Annovazzi and Emanuele D'Amico and Paola Cavalla and Elisabetta Capello and Ruggero Capra and Daniela Galimberti and Gioacchino Tedeschi and Luigi Grimaldi and Maurizio Leone and Sandra D'Alfonso and Vittorio Martinelli and Giancarlo Comi and Filippo Martinelli-Boneschi",

note = "Funding Information: The project was sponsored by the Grant Giovani Ricercatori 2007 (D.lgs 502/92) from the Italian Ministry of Health, FISM (Projects: 2008/R/15 and Progetto Speciale Immunochip), Cariplo Foundation (Grant 2010.0728), and CRT Foundation of Turin Italy. ",

year = "2014",

month = may,

doi = "10.1007/s10072-014-1650-7",

language = "English",

volume = "35",

pages = "789--791",

journal = "Neurological Sciences",

issn = "1590-1874",

publisher = "Springer-Verlag Italia s.r.l.",

number = "5",

}

Guaschino, C, Esposito, F, Liberatore, G, Colombo, B, Annovazzi, P, D'Amico, E, Cavalla, P, Capello, E, Capra, R, Galimberti, D, Tedeschi, G, Grimaldi, L, Leone, M, D'Alfonso, S, Martinelli, V, Comi, G & Martinelli-Boneschi, F 2014, 'Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis', Neurological Sciences, vol. 35, n. 5, pagg. 789-791. https://doi.org/10.1007/s10072-014-1650-7

TY - JOUR

T1 - Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

AU - Guaschino, Clara

AU - Esposito, Federica

AU - Liberatore, Giuseppe

AU - Colombo, Bruno

AU - Annovazzi, Pietro

AU - D'Amico, Emanuele

AU - Cavalla, Paola

AU - Capello, Elisabetta

AU - Capra, Ruggero

AU - Galimberti, Daniela

AU - Tedeschi, Gioacchino

AU - Grimaldi, Luigi

AU - Leone, Maurizio

AU - D'Alfonso, Sandra

AU - Martinelli, Vittorio

AU - Comi, Giancarlo

AU - Martinelli-Boneschi, Filippo

N1 - Funding Information: The project was sponsored by the Grant Giovani Ricercatori 2007 (D.lgs 502/92) from the Italian Ministry of Health, FISM (Projects: 2008/R/15 and Progetto Speciale Immunochip), Cariplo Foundation (Grant 2010.0728), and CRT Foundation of Turin Italy.

PY - 2014/5

Y1 - 2014/5

N2 - Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.

AB - Multiple sclerosis (MS) is a complex disease triggered by environmental and genetic agents, and clinically characterized by bout onset (BOMS) or progressive onset (PrMS). We collected clinical and familial aggregation data in a cohort of 518 Italian PrMS patients, and compared with 400 BOMS cases. An increased prevalence of MS in first-degree relatives of Italian PrMS was found. Familial aggregation is not influenced by probands' clinical course, and there is no disease course concordance within MS families. These data are useful in counseling MS patients affected with different clinical courses of the disease.

KW - Multiple sclerosis

KW - Progressive

KW - Recurrence risk

KW - Relapsing-remitting

UR - http://www.scopus.com/inward/record.url?scp=84901380570&partnerID=8YFLogxK

U2 - 10.1007/s10072-014-1650-7

DO - 10.1007/s10072-014-1650-7

M3 - Article

SN - 1590-1874

VL - 35

SP - 789

EP - 791

JO - Neurological Sciences

JF - Neurological Sciences

IS - 5

ER -

Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

Abstract

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