Abstract
We describe a simple and novel protocol for the synthesis of tetrahydro-1,4-benzodiazepin-2-ones with three points of diversity, exploiting the acylating properties of the recently rediscovered Ugi-imide. The final compounds can be easily prepared in three synthetic steps using a multi-component reaction, a Staudinger reduction, and an acylative protocol, with good to excellent yields for each synthetic step (Figure presented).
Lingua originale | Inglese |
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pagine (da-a) | 10258-10262 |
Numero di pagine | 5 |
Rivista | Journal of Organic Chemistry |
Volume | 76 |
Numero di pubblicazione | 24 |
DOI | |
Stato di pubblicazione | Pubblicato - 16 dic 2011 |