@article{b20f1c7376844f09980300e8be3725fc,
title = "Expeditious N-Monoalkylation of 1,4,7,10-Tetraazacyclododecane (Cyclen) via Formamido Protection",
abstract = "The reaction of cyclen 1 with chloral hydrate afforded exclusively 1,4,7-triformylcyclen 2 in high yield; the triprotected macrocycle was easily alkylated with various electrophiles in good to excellent yields. The alkaline removal of the formyl groups provided a selective entry into N-monosubstituted cyclen derivatives.",
author = "V. BOLDRINI and GIOVENZANA, {Giovanni Battista} and R. PAGLIARIN and G. PALMISANO and M. SISTI",
note = "Funding Information: This work was supported by CNR, Rome, through Target project on {\textquoteleft}Biotechnology{\textquoteright}. Professor S. Aime (University of Turin) is gratefully acknowledged for his interest and helpful discussions. ",
year = "2000",
doi = "10.1016/S0040-4039(00)01092-3",
language = "English",
volume = "41",
pages = "6527--6530",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "33",
}