Exclusive radiotherapy for early-stage glottic cancer: A single-institution retrospective analysis with a focus on voice quality

Ilenia Potenza, Pierfrancesco Franco, Francesco Moretto, Serena Badellino, Vittoria Balcet, Giuseppe Rossi, Vincenzo Landolfo, Giuseppe Riva, Giancarlo Pecorari, Riccardo Ragona, Monica Rampino, Umberto Ricardi

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Aim: To report on clinical outcomes of patients with early-stage glottic cancer treated with exclusive radiotherapy with specific analysis of voice quality. Patients and Methods: A consecutive cohort of 55 patients with early glottic cancer was retrospectively analyzed. Patients were treated with exclusive radiation up to a conventionally fractionated total dose of 66-70 Gy with a 3-dimensional conformal technique. Oncological outcomes and toxicity profiles were investigated. A sub-sample of this cohort was also analyzed in terms of voice quality employing subjective and objective tools such as the Voice Handicap Index-10 (VHI-10) and the Multidimensional Voice Program (MDVP") software and was compared to a group of similar patients treated with CO2 laser cordectomy. Results: after a median observation time of 74.5 months, 5- and 10-year local control was 89% [95% confidence interval (CI)=70.7-93.1%] and 86% (95% CI=68.7-89.6%), respectively. Larynx-preservation rate was 91.8% (95% CI=82.4%-94.9%) at 10 years. Five- and 10-year actuarial overall survival was 72% (95% CI=50.4-79.2%) and 56% (95% CI=48.7-64.3%). Maximum detected acute toxicity included G3 dermatitis (5.4%) and G4 dyspnea (1.8%). Late toxicity profile was mild. VHI-10 scores showed a mild voice disability in both groups, with no statistically significant difference (p=0.12), even when investigating different domains. Patients treated with radiation had a lower deterioration rate in all parameters excluding low voice, interruptions of sound and diplophony. Conclusion: Exclusive radiation proved an effective treatment for patients with early glottic cancer in terms of both oncological outcome and voice quality.

Lingua originaleInglese
pagine (da-a)4155-4160
Numero di pagine6
RivistaAnticancer Research
Volume35
Numero di pubblicazione7
Stato di pubblicazionePubblicato - 1 lug 2015
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'Exclusive radiotherapy for early-stage glottic cancer: A single-institution retrospective analysis with a focus on voice quality'. Insieme formano una fingerprint unica.

Cita questo