Excess body weight, liver steatosis, and early fibrosis progression due to hepatitis C recurrence after liver transplantation

Pierluigi Toniutto, Carlo Fabris, Claudio Avellini, Rosalba Minisini, Davide Bitetto, Elisabetta Rossi, Carlo Smirne, Mario Pirisi

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Aim: To investigate how weight gain after OLT affects the speed of fibrosis progression (SFP) during recurrent hepatitis C virus (HCV) infection of the graft. Methods: Ninety consecutive patients (63 males, median age 53 years; 55 with HCV-related liver disease), transplanted at a single institution, were studied. All were followed for at least 2 years after OLT and had at least one follow-up graft biopsy, performed not earlier than 1 year after the transplant operation. For each biopsy, a single, experienced pathologist gave an estimate of both the staging according to Ishak and the degree of hepatic steatosis. The SFP was quantified in fibrosis units/month (FU/mo). The lipid metabolism status of patients was summarized by the plasma triglycerides/cholesterol (T/C) ratio. Body mass index (BMI) was measured before OLT, and 1 and 2 years after it. Results: In the HCV positive group, the highest SFP was observed in the first post-OLT year. At that time point, a SFP ≤0.100 FU/mo was observed more frequently among recipients who had received their graft from a young donor and had a pre-transplant BMI value >26.0 kg/m2. At completion of the first post-transplant year, a BMI value >26.5 kg/m2 was associated with a T/C ratio ≤1. The proportion of patients with SFP >0.100 FU/mo descended in the following order: female recipients with a high T/C ratio, male recipients with high T/C ratio, and recipients of either gender with low T/C ratio. Hepatic steatosis was observed more frequently in recipients who, in the first post-transplant year, had increased their BMI ≥1.5 kg/m2 in comparison to the pre-transplant value. Hepatic steatosis was inversely associated with the staging score. Conclusion: Among HCV positive recipients, excess weight gain post-OLT does not represent a factor favoring early liver fibrosis development and might even be protective against it.

Lingua originaleInglese
pagine (da-a)5944-5950
Numero di pagine7
RivistaWorld Journal of Gastroenterology
Volume11
Numero di pubblicazione38
DOI
Stato di pubblicazionePubblicato - 14 ott 2005

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