TY - JOUR
T1 - Estrogen derivatives of transition metal carbonyl clusters for analytical detection enhancement
AU - OSELLA, Domenico
AU - GAMBINO, O
AU - GOBETTO, R
AU - NERVI, C
AU - RAVERA, Mauro
AU - JAOUEN, G.
N1 - Funding Information:
We thank the Minister0 dell’Universita e della Ricerca Scientifica e Tecnologica (MURST, Rome) and the Council of National Research (CNR, Rome) for financial support, Johnson Matthey Ltd. for a generous loan of RuCl, and OsO,, and P. A. Loveday (University Chemical Laboratory, Cambridge, UK) for high-pressure synthesis of M3(C0)12 (M=Ru, OS). Finally, we gratefully thank Enrico Mocellin, (on study leave from Deakin University, Australia) for helpful discussions.
PY - 1992
Y1 - 1992
N2 - We herein describe the labelling of ethynylestradiol with metal carbonyl fragments, namely -Co2(CO)6, -M3(μ- CO)(CO)9 (M=Ru, Os) and -Ru3(μ-H)(CO)9. The solution structure of Ru3(μ-CO)(CO)9 (ethynylestradiol) cluster has been studied by means of variable-temperature (VT) 13C NMR spectroscopy. This derivatization can be useful for detection enhancement in high-performance liquid chromatography (HPLC) separation, since the metal carbonyl moieties act as efficient markers for the UV detection mode at the usually employed 254 nm wavelength.
AB - We herein describe the labelling of ethynylestradiol with metal carbonyl fragments, namely -Co2(CO)6, -M3(μ- CO)(CO)9 (M=Ru, Os) and -Ru3(μ-H)(CO)9. The solution structure of Ru3(μ-CO)(CO)9 (ethynylestradiol) cluster has been studied by means of variable-temperature (VT) 13C NMR spectroscopy. This derivatization can be useful for detection enhancement in high-performance liquid chromatography (HPLC) separation, since the metal carbonyl moieties act as efficient markers for the UV detection mode at the usually employed 254 nm wavelength.
UR - https://iris.uniupo.it/handle/11579/32405
U2 - 10.1016/S0020-1693(00)83174-6
DO - 10.1016/S0020-1693(00)83174-6
M3 - Article
SN - 0020-1693
VL - 192
SP - 65
EP - 70
JO - Inorganica Chimica Acta
JF - Inorganica Chimica Acta
IS - 1
ER -