Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Anne Vessières; Siden Top; Colette Vaillant; Domenico Osella; Jean‐Paul ‐P Mornon; Gérard Jaouen

doi:10.1002/anie.199207531

Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

Anne Vessières
, Siden Top
, Colette Vaillant
, Domenico Osella
, Jean‐Paul ‐P Mornon
, Gérard Jaouen

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1–4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.)

Lingua originale	Inglese
pagine (da-a)	753-755
Numero di pagine	3
Rivista	Angewandte Chemie - International Edition
Volume	31
Numero di pubblicazione	6
DOI	https://doi.org/10.1002/anie.199207531
Stato di pubblicazione	Pubblicato - giu 1992
Pubblicato esternamente	Sì

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title = "Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor",

abstract = "Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1–4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.)",

author = "Anne Vessi{\`e}res and Siden Top and Colette Vaillant and Domenico Osella and Mornon, \{Jean‐Paul ‐P\} and G{\'e}rard Jaouen",

year = "1992",

month = jun,

doi = "10.1002/anie.199207531",

language = "English",

volume = "31",

pages = "753--755",

journal = "Angewandte Chemie - International Edition",

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Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor. / Vessières, Anne; Top, Siden; Vaillant, Colette et al.
In: Angewandte Chemie - International Edition, Vol. 31, N. 6, 06.1992, pag. 753-755.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins

T2 - Application to the Estradiol Receptor

AU - Vessières, Anne

AU - Top, Siden

AU - Vaillant, Colette

AU - Osella, Domenico

AU - Mornon, Jean‐Paul ‐P

AU - Jaouen, Gérard

PY - 1992/6

Y1 - 1992/6

N2 - Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1–4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.)

AB - Derivatizing biomolecules with transition‐metal fragments can be a useful approach to some biochemical problems, for example in labeling hormone receptors. The estradiol derivatives 1–4 deactivate the estradiol receptor to varying degrees, allowing conclusions to be drawn concerning the chemical environment of the binding site. (Figure Presented.)

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DO - 10.1002/anie.199207531

M3 - Article

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 6

ER -

Estradiols Modified by Metal Carbonyl Clusters as Suicide Substrates for the Study of Receptor Proteins: Application to the Estradiol Receptor

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