Abstract
Glucagon-like peptide 1 (GLP-1) is an intestinal hormone secreted after the ingestion of various nutrients. The main role of GLP-1 is to stimulate insulin secretion in a glucose-dependent manner. However, the expression of GLP-1 receptor was found to be expressed in a variety of tissues beyond pancreas such as lung, stomach, intestine, kidney, heart and brain. Beyond pancreas, a beneficial effect of GLP-1 on body weight reduction has been shown, suggesting its role for the treatment of obesity. In addition, GLP-1 has been demonstrated to reduce cardiovascular risk factors and to have a direct cardioprotective effect, fostering heart recovery after ischemic injury. Further, data from both experimental animal models and human studies have shown beneficial effect of GLP-1 on bone metabolism, either directly or indirectly on bone cells.
| Lingua originale | Inglese |
|---|---|
| pagine (da-a) | 115 |
| Numero di pagine | 1 |
| Rivista | Journal of Endocrinological Investigation |
| Volume | 38 |
| Numero di pubblicazione | 1 |
| DOI |
|
| Stato di pubblicazione | Pubblicato - 1 gen 2015 |
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