Epiregulin induces human SK-N-BE cell differentiation through ERK1/2 signaling pathway

Manuela Rizzi; Pamela Pittarella; Maurizio Sabbatini; Filippo Renò

doi:10.3109/08977194.2013.795958

Epiregulin induces human SK-N-BE cell differentiation through ERK1/2 signaling pathway

Manuela Rizzi, Pamela Pittarella, Maurizio Sabbatini, Filippo Renò

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Epidermal growth factor (EGF) and other EGF-related growth factors, such as transforming growth factor-α, are able to stimulate neuroblastoma (NB) cell proliferation. Epiregulin (Epi) is a growth factor belonging to the EGF family known to be more potent than EGF in mediating mitogenic signals. In this study, we tested the ability of Epi to stimulate a human NB cell line (SK-N-BE) proliferation. Surprisingly, Epi (50-1000ng/ml) induced a reduction in SK-N-BE proliferation along with a morphological differentiation, associated with an increase in MMP-9 expression. Moreover, Epi-induced differentiation was inhibited by ERK1/2 phosphorilation inhibition. In conclusion, Epi could represent a novel and useful tool to oppose NB cell proliferation.

Lingua originale	Inglese
pagine (da-a)	90-97
Numero di pagine	8
Rivista	Growth Factors
Volume	31
Numero di pubblicazione	3
DOI	https://doi.org/10.3109/08977194.2013.795958
Stato di pubblicazione	Pubblicato - giu 2013

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10.3109/08977194.2013.795958

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title = "Epiregulin induces human SK-N-BE cell differentiation through ERK1/2 signaling pathway",

abstract = "Epidermal growth factor (EGF) and other EGF-related growth factors, such as transforming growth factor-α, are able to stimulate neuroblastoma (NB) cell proliferation. Epiregulin (Epi) is a growth factor belonging to the EGF family known to be more potent than EGF in mediating mitogenic signals. In this study, we tested the ability of Epi to stimulate a human NB cell line (SK-N-BE) proliferation. Surprisingly, Epi (50-1000ng/ml) induced a reduction in SK-N-BE proliferation along with a morphological differentiation, associated with an increase in MMP-9 expression. Moreover, Epi-induced differentiation was inhibited by ERK1/2 phosphorilation inhibition. In conclusion, Epi could represent a novel and useful tool to oppose NB cell proliferation.",

keywords = "Differentiation, ERK1/2, MMPs, Neuroblastoma, SK-N-BE cell line",

author = "Manuela Rizzi and Pamela Pittarella and Maurizio Sabbatini and Filippo Ren{\`o}",

year = "2013",

month = jun,

doi = "10.3109/08977194.2013.795958",

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T1 - Epiregulin induces human SK-N-BE cell differentiation through ERK1/2 signaling pathway

AU - Rizzi, Manuela

AU - Pittarella, Pamela

AU - Sabbatini, Maurizio

AU - Renò, Filippo

PY - 2013/6

Y1 - 2013/6

N2 - Epidermal growth factor (EGF) and other EGF-related growth factors, such as transforming growth factor-α, are able to stimulate neuroblastoma (NB) cell proliferation. Epiregulin (Epi) is a growth factor belonging to the EGF family known to be more potent than EGF in mediating mitogenic signals. In this study, we tested the ability of Epi to stimulate a human NB cell line (SK-N-BE) proliferation. Surprisingly, Epi (50-1000ng/ml) induced a reduction in SK-N-BE proliferation along with a morphological differentiation, associated with an increase in MMP-9 expression. Moreover, Epi-induced differentiation was inhibited by ERK1/2 phosphorilation inhibition. In conclusion, Epi could represent a novel and useful tool to oppose NB cell proliferation.

AB - Epidermal growth factor (EGF) and other EGF-related growth factors, such as transforming growth factor-α, are able to stimulate neuroblastoma (NB) cell proliferation. Epiregulin (Epi) is a growth factor belonging to the EGF family known to be more potent than EGF in mediating mitogenic signals. In this study, we tested the ability of Epi to stimulate a human NB cell line (SK-N-BE) proliferation. Surprisingly, Epi (50-1000ng/ml) induced a reduction in SK-N-BE proliferation along with a morphological differentiation, associated with an increase in MMP-9 expression. Moreover, Epi-induced differentiation was inhibited by ERK1/2 phosphorilation inhibition. In conclusion, Epi could represent a novel and useful tool to oppose NB cell proliferation.

KW - Differentiation

KW - ERK1/2

KW - MMPs

KW - Neuroblastoma

KW - SK-N-BE cell line

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Epiregulin induces human SK-N-BE cell differentiation through ERK1/2 signaling pathway

Abstract

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