Epigenome programming by Polycomb and Trithorax proteins

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Polycomb group (PcG) and Trithorax group (TrxG) proteins work, respectively, to maintain repressed or active transcription states of developmentally regulated genes through cell division. Data accumulated in the recent years have increased our understanding of the mechanisms by which PcG and TrxG proteins regulate gene expression. The discovery that histone methylation can serve as a specific mark for PcG and TrxG complexes has provided new insight into the mechanistic function of this cell-memory system. © 2005 NRC Canada.
Lingua originaleInglese
pagine (da-a)322-331
Numero di pagine10
RivistaBiochemistry and Cell Biology
Volume83
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - 2005

Keywords

  • Cell memory
  • Epigenome
  • Noncoding RNA
  • Polycomb
  • RNAi
  • Trithorax

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