Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues

Carola Marzi; Lesca M Holdt; GIOVANNI FIORITO; Pei Chien Tsai; Anja Kretschmer; Simone Wahl; GUARRERA Simonetta; Daniel Teupser; Tim D Spector; Licia Iacoviello; Carlotta SACERDOTE; Konstantin Strauch; Serene Lee; Wolfgang E Thasler; Annette Peters; Barbara Thorand; Petra Wolf; Holger Prokisch; Rosario Tumino; Christian Gieger; Vittorio Krogh; Salvatore Panico; Jordana T Bell; MATULLO Giuseppe; Melanie Waldenberger; Harald Grallert; Wolfgang Koenig

doi:10.1371/journal.pone.0166015

Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues

Carola Marzi, Lesca M Holdt, GIOVANNI FIORITO, Pei Chien Tsai, Anja Kretschmer, Simone Wahl, GUARRERA Simonetta, Daniel Teupser, Tim D Spector, Licia Iacoviello, Carlotta SACERDOTE, Konstantin Strauch, Serene Lee, Wolfgang E Thasler, Annette Peters, Barbara Thorand, Petra Wolf, Holger Prokisch, Rosario Tumino, Christian GiegerVittorio Krogh, Salvatore Panico, Jordana T Bell, MATULLO Giuseppe, Melanie Waldenberger, Harald Grallert, Wolfgang Koenig

Dipartimento di Scienze della Salute

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Elevated levels of C-reactive protein (CRP, determined by a high-sensitivity assay) indicate low-grade inflammation which is implicated in many age-related disorders. Epigenetic studies on CRP might discover molecular mechanisms underlying CRP regulation. We aimed to identify DNA methylation sites related to CRP concentrations in cells and tissues regulating low-grade inflammation.

Lingua originale	Inglese
pagine (da-a)	e0166015-e0166015
Numero di pagine	14
Rivista	PLoS ONE
Volume	11
Numero di pubblicazione	11
DOI	https://doi.org/10.1371/journal.pone.0166015
Stato di pubblicazione	Pubblicato - 2016

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10.1371/journal.pone.0166015

https://hdl.handle.net/11579/176987

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Marzi, C., Holdt, L. M., FIORITO, GIOVANNI., Tsai, P. C., Kretschmer, A., Wahl, S., Simonetta, GUARRERA., Teupser, D., Spector, T. D., Iacoviello, L., SACERDOTE, C., Strauch, K., Lee, S., Thasler, W. E., Peters, A., Thorand, B., Wolf, P., Prokisch, H., Tumino, R., ... Koenig, W. (2016). Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues. PLoS ONE, 11(11), e0166015-e0166015. https://doi.org/10.1371/journal.pone.0166015

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title = "Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues",

abstract = "Elevated levels of C-reactive protein (CRP, determined by a high-sensitivity assay) indicate low-grade inflammation which is implicated in many age-related disorders. Epigenetic studies on CRP might discover molecular mechanisms underlying CRP regulation. We aimed to identify DNA methylation sites related to CRP concentrations in cells and tissues regulating low-grade inflammation.",

author = "Carola Marzi and Holdt, {Lesca M} and GIOVANNI FIORITO and Tsai, {Pei Chien} and Anja Kretschmer and Simone Wahl and GUARRERA Simonetta and Daniel Teupser and Spector, {Tim D} and Licia Iacoviello and Carlotta SACERDOTE and Konstantin Strauch and Serene Lee and Thasler, {Wolfgang E} and Annette Peters and Barbara Thorand and Petra Wolf and Holger Prokisch and Rosario Tumino and Christian Gieger and Vittorio Krogh and Salvatore Panico and Bell, {Jordana T} and MATULLO Giuseppe and Melanie Waldenberger and Harald Grallert and Wolfgang Koenig",

year = "2016",

doi = "10.1371/journal.pone.0166015",

language = "English",

volume = "11",

pages = "e0166015--e0166015",

journal = "PLoS ONE",

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Marzi, C, Holdt, LM, FIORITO, GIOVANNI, Tsai, PC, Kretschmer, A, Wahl, S, Simonetta, GUARRERA, Teupser, D, Spector, TD, Iacoviello, L, SACERDOTE, C, Strauch, K, Lee, S, Thasler, WE, Peters, A, Thorand, B, Wolf, P, Prokisch, H, Tumino, R, Gieger, C, Krogh, V, Panico, S, Bell, JT, Giuseppe, MATULLO, Waldenberger, M, Grallert, H & Koenig, W 2016, 'Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues', PLoS ONE, vol. 11, n. 11, pagg. e0166015-e0166015. https://doi.org/10.1371/journal.pone.0166015

TY - JOUR

T1 - Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues

AU - Marzi, Carola

AU - Holdt, Lesca M

AU - FIORITO, GIOVANNI

AU - Tsai, Pei Chien

AU - Kretschmer, Anja

AU - Wahl, Simone

AU - Simonetta, GUARRERA

AU - Teupser, Daniel

AU - Spector, Tim D

AU - Iacoviello, Licia

AU - SACERDOTE, Carlotta

AU - Strauch, Konstantin

AU - Lee, Serene

AU - Thasler, Wolfgang E

AU - Peters, Annette

AU - Thorand, Barbara

AU - Wolf, Petra

AU - Prokisch, Holger

AU - Tumino, Rosario

AU - Gieger, Christian

AU - Krogh, Vittorio

AU - Panico, Salvatore

AU - Bell, Jordana T

AU - Giuseppe, MATULLO

AU - Waldenberger, Melanie

AU - Grallert, Harald

AU - Koenig, Wolfgang

PY - 2016

Y1 - 2016

N2 - Elevated levels of C-reactive protein (CRP, determined by a high-sensitivity assay) indicate low-grade inflammation which is implicated in many age-related disorders. Epigenetic studies on CRP might discover molecular mechanisms underlying CRP regulation. We aimed to identify DNA methylation sites related to CRP concentrations in cells and tissues regulating low-grade inflammation.

AB - Elevated levels of C-reactive protein (CRP, determined by a high-sensitivity assay) indicate low-grade inflammation which is implicated in many age-related disorders. Epigenetic studies on CRP might discover molecular mechanisms underlying CRP regulation. We aimed to identify DNA methylation sites related to CRP concentrations in cells and tissues regulating low-grade inflammation.

UR - https://iris.uniupo.it/handle/11579/176987

U2 - 10.1371/journal.pone.0166015

DO - 10.1371/journal.pone.0166015

M3 - Article

SN - 1932-6203

VL - 11

SP - e0166015-e0166015

JO - PLoS ONE

JF - PLoS ONE

IS - 11

ER -

Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues

Abstract

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