TY - JOUR
T1 - EPIC-Heart
T2 - The cardiovascular component of a prospective study of nutritional, lifestyle and biological factors in 520,000 middle-aged participants from 10 European countries
AU - Danesh, John
AU - Saracci, Rodolfo
AU - Berglund, Göran
AU - Feskens, Edith
AU - Overvad, Kim
AU - Panico, Salvatore
AU - Thompson, Simon
AU - Fournier, Agnès
AU - Clavel-Chapelon, Françoise
AU - Canonico, Marianne
AU - Kaaks, Rudolf
AU - Linseisen, Jakob
AU - Boeing, Heiner
AU - Pischon, Tobias
AU - Weikert, Cornelia
AU - Olsen, Anja
AU - Tjønneland, Anne
AU - Johnsen, Søren Paaske
AU - Jensen, Majken Karoline
AU - Quirós, Jose R.
AU - Svatetz, Carlos Alberto Gonzalez
AU - Pérez, Maria José Sánchez
AU - Larrañaga, Nerea
AU - Sanchez, Carmen Navarro
AU - Iribas, Concepción Moreno
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Wareham, Nick
AU - Key, Timothy
AU - Roddam, Andrew
AU - Trichopoulou, Antonia
AU - Benetou, Vassiliki
AU - Trichopoulos, Dimitrios
AU - Masala, Giovanna
AU - Sieri, Sabina
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - Mattiello, Amalia
AU - Verschuren, W. M.Monique
AU - Bueno-De-Mesquita, H. Bas
AU - Grobbee, Diederick E.
AU - Van Der Schouw, Yvonne T.
AU - Melander, Olle
AU - Hallmans, Göran
AU - Wennberg, Patrik
AU - Lund, Eiliv
AU - Kumle, Merethe
AU - Skeie, Guri
AU - Ferrari, Pietro
AU - Slimani, Nadia
AU - Norat, Teresa
AU - Riboli, Elio
PY - 2007/2
Y1 - 2007/2
N2 - EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition (EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle (especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants (366,521 women and 153,457 men, mostly aged 35-70 years) in 23 centres in 10 European countries commenced follow-up for cause- specific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors.
AB - EPIC-Heart is the cardiovascular component of the European Prospective Investigation into Cancer and Nutrition (EPIC), a multi-centre prospective cohort study investigating the relationship between nutrition and major chronic disease outcomes. Its objective is to advance understanding about the separate and combined influences of lifestyle (especially dietary), environmental, metabolic and genetic factors in the development of cardiovascular diseases by making best possible use of the unusually informative database and biological samples in EPIC. Between 1992 and 2000, 519,978 participants (366,521 women and 153,457 men, mostly aged 35-70 years) in 23 centres in 10 European countries commenced follow-up for cause- specific mortality, cancer incidence and major cardiovascular morbidity. Dietary information was collected with quantitative questionnaires or semi-quantitative food frequency questionnaires, including a 24-h dietary recall sub-study to help calibrate the dietary measurements. Information was collected on physical activity, tobacco smoking, alcohol consumption, occupational history, socio-economic status, and history of previous illnesses. Anthropometric measurements and blood pressure recordings were made in the majority of participants. Blood samples were taken from 385,747 individuals, from which plasma, serum, red cells, and buffy coat fractions were separated and aliquoted for long-term storage. By 2004, an estimated 10,000 incident fatal and non-fatal coronary and stroke events had been recorded. The first cycle of EPIC-Heart analyses will assess associations of coronary mortality with several prominent dietary hypotheses and with established cardiovascular risk factors. Subsequent analyses will extend this approach to non-fatal cardiovascular outcomes and to further dietary, biochemical and genetic factors.
KW - Diet
KW - EPIC Heart
KW - Prospective study
KW - Study protocol
UR - https://www.scopus.com/pages/publications/33947383651
U2 - 10.1007/s10654-006-9096-8
DO - 10.1007/s10654-006-9096-8
M3 - Article
SN - 0393-2990
VL - 22
SP - 129
EP - 141
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 2
ER -
