EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

F. Broglio; F. Boutignon; A. Benso; C. Gottero; F. Prodam; E. Arvat; C. Ghè; F. Catapano; A. Torsello; V. Locatelli; G. Muccioli; D. Boeglin; V. Guerlavais; J. A. Fehrentz; J. Martinez; Ezio Ghigo; R. Deghenghi

doi:10.1007/BF03345096

EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

F. Broglio
, F. Boutignon
, A. Benso
, C. Gottero
, F. Prodam
, E. Arvat
, C. Ghè
, F. Catapano
, A. Torsello
, V. Locatelli
, G. Muccioli
, D. Boeglin
, V. Guerlavais
, J. A. Fehrentz
, J. Martinez
, Ezio Ghigo
, R. Deghenghi

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

Lingua originale	Inglese
pagine (da-a)	RC26-RC28
Rivista	Journal of Endocrinological Investigation
Volume	25
Numero di pubblicazione	8
DOI	https://doi.org/10.1007/BF03345096
Stato di pubblicazione	Pubblicato - set 2002
Pubblicato esternamente	Sì

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10.1007/BF03345096

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Broglio, F., Boutignon, F., Benso, A., Gottero, C., Prodam, F., Arvat, E., Ghè, C., Catapano, F., Torsello, A., Locatelli, V., Muccioli, G., Boeglin, D., Guerlavais, V., Fehrentz, J. A., Martinez, J., Ghigo, E., & Deghenghi, R. (2002). EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man. Journal of Endocrinological Investigation, 25(8), RC26-RC28. https://doi.org/10.1007/BF03345096

@article{68d7ce33388f4569aa389373b8d7dffe,

title = "EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man",

abstract = "EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.",

keywords = "GH, Ghrelin receptors, Humans, Oral administration, Synthetic GH secretagogues",

author = "F. Broglio and F. Boutignon and A. Benso and C. Gottero and F. Prodam and E. Arvat and C. Gh{\`e} and F. Catapano and A. Torsello and V. Locatelli and G. Muccioli and D. Boeglin and V. Guerlavais and Fehrentz, \{J. A.\} and J. Martinez and Ezio Ghigo and R. Deghenghi",

year = "2002",

month = sep,

doi = "10.1007/BF03345096",

language = "English",

volume = "25",

pages = "RC26--RC28",

journal = "Journal of Endocrinological Investigation",

issn = "0391-4097",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "8",

}

Broglio, F, Boutignon, F, Benso, A, Gottero, C, Prodam, F, Arvat, E, Ghè, C, Catapano, F, Torsello, A, Locatelli, V, Muccioli, G, Boeglin, D, Guerlavais, V, Fehrentz, JA, Martinez, J, Ghigo, E & Deghenghi, R 2002, 'EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man', Journal of Endocrinological Investigation, vol. 25, n. 8, pagg. RC26-RC28. https://doi.org/10.1007/BF03345096

TY - JOUR

T1 - EP1572

T2 - A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

AU - Broglio, F.

AU - Boutignon, F.

AU - Benso, A.

AU - Gottero, C.

AU - Prodam, F.

AU - Arvat, E.

AU - Ghè, C.

AU - Catapano, F.

AU - Torsello, A.

AU - Locatelli, V.

AU - Muccioli, G.

AU - Boeglin, D.

AU - Guerlavais, V.

AU - Fehrentz, J. A.

AU - Martinez, J.

AU - Ghigo, Ezio

AU - Deghenghi, R.

PY - 2002/9

Y1 - 2002/9

N2 - EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

AB - EP1572 (JMV1843 [Aib-DTrp-DgTrp-CHO]) is a new peptido-mimetic GH secretagogue (GHS) showing binding potency to the GHS-receptor in animal and human tissues similar to that of ghrelin and peptidyl GHS. EP1572 induces marked GH increase after sc administration in neonatal rats. Preliminary data in 2 normal young men show that: 1) acute iv EP1572 administration (1.0 μg/kg) induces strong and selective increase of GH levels; 2) single oral EP1572 administration strongly and reproducibly increases GH levels even after a dose as low as 0.06 mg/kg. Thus, EP1572 is a new peptido-mimetic GHS with potent and selective GH-releasing activity.

KW - GH

KW - Ghrelin receptors

KW - Humans

KW - Oral administration

KW - Synthetic GH secretagogues

UR - https://www.scopus.com/pages/publications/0036733916

U2 - 10.1007/BF03345096

DO - 10.1007/BF03345096

M3 - Article

SN - 0391-4097

VL - 25

SP - RC26-RC28

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

IS - 8

ER -

EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man

Abstract

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