Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors

Wenkai Pan; Anastasia Grigoryeva; Corrado Bacchiocchi; Pablo Ballester; Luca Valgimigli; MANUEL PETROSELLI

doi:10.1021/acs.orglett.5c04339

Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors

Wenkai Pan
, Anastasia Grigoryeva
, Corrado Bacchiocchi
, Pablo Ballester
, Luca Valgimigli
, MANUEL PETROSELLI

Dipartimento di Scienze e Innovazione Tecnologica

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

: We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals). The chemical structure and shape of the molecular receptors affect the affinity towards free-radicals, while host-guest interactions are used to fine-tune the HAT reactivity, mimicking enzyme modulation in biological systems.

Lingua originale	Inglese
Rivista	Organic Letters
DOI	https://doi.org/10.1021/acs.orglett.5c04339
Stato di pubblicazione	Pubblicato - 2025

Accesso al documento

10.1021/acs.orglett.5c04339

https://hdl.handle.net/11579/221584

Altri file e collegamenti

handle

Cita questo

@article{03a87e849bbc4dca992abf53019639a4,

title = "Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors",

abstract = ": We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals). The chemical structure and shape of the molecular receptors affect the affinity towards free-radicals, while host-guest interactions are used to fine-tune the HAT reactivity, mimicking enzyme modulation in biological systems.",

author = "Wenkai Pan and Anastasia Grigoryeva and Corrado Bacchiocchi and Pablo Ballester and Luca Valgimigli and MANUEL PETROSELLI",

year = "2025",

doi = "10.1021/acs.orglett.5c04339",

language = "English",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

}

TY - JOUR

T1 - Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors

AU - Pan, Wenkai

AU - Grigoryeva, Anastasia

AU - Bacchiocchi, Corrado

AU - Ballester, Pablo

AU - Valgimigli, Luca

AU - PETROSELLI, MANUEL

PY - 2025

Y1 - 2025

N2 - : We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals). The chemical structure and shape of the molecular receptors affect the affinity towards free-radicals, while host-guest interactions are used to fine-tune the HAT reactivity, mimicking enzyme modulation in biological systems.

AB - : We report a series of endo-functionalized molecular receptors based on a calix[4]pyrrole scaffold, which exhibit Hydrogen Atom Transfer (HAT) reactivity towards free-radicals (e.g., peroxyl radicals). The chemical structure and shape of the molecular receptors affect the affinity towards free-radicals, while host-guest interactions are used to fine-tune the HAT reactivity, mimicking enzyme modulation in biological systems.

UR - https://iris.uniupo.it/handle/11579/221584

U2 - 10.1021/acs.orglett.5c04339

DO - 10.1021/acs.orglett.5c04339

M3 - Article

SN - 1523-7060

JO - Organic Letters

JF - Organic Letters

ER -

Enzyme-like Hydrogen Atom Transfer (HAT) Based Endo-Functionalized Molecular Receptors

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo