Enzymatic impairment induced by biological aldehydes in intact rat liver cells

G. Poli; E. Chiarpotto; F. Biasi; R. Pavia; E. Albano; M. U. Dianzani

Enzymatic impairment induced by biological aldehydes in intact rat liver cells

G. Poli, E. Chiarpotto, F. Biasi, R. Pavia, E. Albano, M. U. Dianzani

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The addition of lipid peroxidation and end-products, 4-hydroxypentenal (HPE), 4-hydroxynonenal (HNE) or hexanal (HEX) to the incubation medium of rat hepatocytes caused a significant decrease of cytochrome P-450 content and inactivation of total cell glucose-6-phosphatase. In particular, the two hydroxyalkenals exerted their inhibitory action at micromolar concentration. These results on intact cells further support a possible damaging effect of aldehydes in pathological conditions in which a stimulation of lipid peroxidation occurs.

Lingua originale	Inglese
pagine (da-a)	71-76
Numero di pagine	6
Rivista	Research Communications in Chemical Pathology and Pharmacology
Volume	38
Numero di pubblicazione	1
Stato di pubblicazione	Pubblicato - 1982
Pubblicato esternamente	Sì

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title = "Enzymatic impairment induced by biological aldehydes in intact rat liver cells",

abstract = "The addition of lipid peroxidation and end-products, 4-hydroxypentenal (HPE), 4-hydroxynonenal (HNE) or hexanal (HEX) to the incubation medium of rat hepatocytes caused a significant decrease of cytochrome P-450 content and inactivation of total cell glucose-6-phosphatase. In particular, the two hydroxyalkenals exerted their inhibitory action at micromolar concentration. These results on intact cells further support a possible damaging effect of aldehydes in pathological conditions in which a stimulation of lipid peroxidation occurs.",

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AU - Poli, G.

AU - Chiarpotto, E.

AU - Biasi, F.

AU - Pavia, R.

AU - Albano, E.

AU - Dianzani, M. U.

PY - 1982

Y1 - 1982

N2 - The addition of lipid peroxidation and end-products, 4-hydroxypentenal (HPE), 4-hydroxynonenal (HNE) or hexanal (HEX) to the incubation medium of rat hepatocytes caused a significant decrease of cytochrome P-450 content and inactivation of total cell glucose-6-phosphatase. In particular, the two hydroxyalkenals exerted their inhibitory action at micromolar concentration. These results on intact cells further support a possible damaging effect of aldehydes in pathological conditions in which a stimulation of lipid peroxidation occurs.

AB - The addition of lipid peroxidation and end-products, 4-hydroxypentenal (HPE), 4-hydroxynonenal (HNE) or hexanal (HEX) to the incubation medium of rat hepatocytes caused a significant decrease of cytochrome P-450 content and inactivation of total cell glucose-6-phosphatase. In particular, the two hydroxyalkenals exerted their inhibitory action at micromolar concentration. These results on intact cells further support a possible damaging effect of aldehydes in pathological conditions in which a stimulation of lipid peroxidation occurs.

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M3 - Article

SN - 0034-5164

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JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

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ER -

Enzymatic impairment induced by biological aldehydes in intact rat liver cells

Abstract

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