TY - JOUR
T1 - Enhancement of Fatty Acid-based Polyurethanes Cytocompatibility by Non-covalent Anchoring of Chondroitin Sulfate
AU - González-Paz, Rodolfo J.
AU - Lligadas, Gerard
AU - Ronda, Juan C.
AU - Galià, Marina
AU - Ferreira, Ana M.
AU - Boccafoschi, Francesca
AU - Ciardelli, Gianluca
AU - Cádiz, Virginia
PY - 2012/12
Y1 - 2012/12
N2 - For tissue engineering purpose biopolymer chondroitin sulfate (CS), one of the major components of cartilage and bone extracellular matrix, was immobilized onto the surface of amino-functionalized polyurethane (PU) films derived from naturally occurring oleic and 10-undecenoic acids. The amino-functionalized PUs were prepared by aminolysis with 1,6-hexamethylenediamine of synthesized PUs containing methyl ester groups. FTIR-ATR, XPS, SEM, and water contact angle measurements were used to confirm the surface changes at each step of treatment, both in morphologies and chemical composition. Cytotoxicity and cell morphology analysis using osteoblast cell line MG63 showed that PU-CS films are suitable materials for cell growth, spreading, and differentiation.
AB - For tissue engineering purpose biopolymer chondroitin sulfate (CS), one of the major components of cartilage and bone extracellular matrix, was immobilized onto the surface of amino-functionalized polyurethane (PU) films derived from naturally occurring oleic and 10-undecenoic acids. The amino-functionalized PUs were prepared by aminolysis with 1,6-hexamethylenediamine of synthesized PUs containing methyl ester groups. FTIR-ATR, XPS, SEM, and water contact angle measurements were used to confirm the surface changes at each step of treatment, both in morphologies and chemical composition. Cytotoxicity and cell morphology analysis using osteoblast cell line MG63 showed that PU-CS films are suitable materials for cell growth, spreading, and differentiation.
KW - Adhesion
KW - Biomaterials
KW - Polyurethanes
KW - Renewable resources
KW - Surface modification
UR - http://www.scopus.com/inward/record.url?scp=84872370513&partnerID=8YFLogxK
U2 - 10.1002/mabi.201200259
DO - 10.1002/mabi.201200259
M3 - Article
SN - 1616-5187
VL - 12
SP - 1697
EP - 1705
JO - Macromolecular Bioscience
JF - Macromolecular Bioscience
IS - 12
ER -
