Enhanced relaxivity of GdIII-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange

Luciano Lattuada; Dávid Horváth; Sonia Colombo Serra; Alberto Fringuello Mingo; Paolo Minazzi; Attila Bényei; Attila Forgács; Franco Fedeli; Eliana Gianolio; Silvio Aime; Giovanni B. Giovenzana; Zsolt Baranyai

doi:10.1039/d0qi01333a

Enhanced relaxivity of Gd^III-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange

Luciano Lattuada, Dávid Horváth, Sonia Colombo Serra, Alberto Fringuello Mingo, Paolo Minazzi, Attila Bényei, Attila Forgács, Franco Fedeli, Eliana Gianolio, Silvio Aime, Giovanni B. Giovenzana, Zsolt Baranyai

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Gadolinium(iii) complexes have been employed for more than 30 years as contrast agents in magnetic resonance imaging (MRI). In order to further improve the diagnostic accuracy of enhanced magnetic resonance images or to provide comparable enhancement at a reduced administered dose, current research is focusing on the development of GdIII-complexes characterized by higher relaxivity. In this study we describe the synthesis and the equilibrium, kinetic, relaxation and structural properties of two new GdIII-complexes based on modified 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) structure which, due to an intramolecular prototropic exchange, display more than two-fold higher relaxivity compared to currently available GdIII-based MRI contrast agents.

Lingua originale	Inglese
pagine (da-a)	1500-1510
Numero di pagine	11
Rivista	Inorganic Chemistry Frontiers
Volume	8
Numero di pubblicazione	6
DOI	https://doi.org/10.1039/d0qi01333a
Stato di pubblicazione	Pubblicato - 21 mar 2021

Accesso al documento

10.1039/d0qi01333a

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Lattuada, L., Horváth, D., Colombo Serra, S., Fringuello Mingo, A., Minazzi, P., Bényei, A., Forgács, A., Fedeli, F., Gianolio, E., Aime, S., Giovenzana, G. B., & Baranyai, Z. (2021). Enhanced relaxivity of Gd^III-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange. Inorganic Chemistry Frontiers, 8(6), 1500-1510. https://doi.org/10.1039/d0qi01333a

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title = "Enhanced relaxivity of GdIII-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange",

abstract = "Gadolinium(iii) complexes have been employed for more than 30 years as contrast agents in magnetic resonance imaging (MRI). In order to further improve the diagnostic accuracy of enhanced magnetic resonance images or to provide comparable enhancement at a reduced administered dose, current research is focusing on the development of GdIII-complexes characterized by higher relaxivity. In this study we describe the synthesis and the equilibrium, kinetic, relaxation and structural properties of two new GdIII-complexes based on modified 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) structure which, due to an intramolecular prototropic exchange, display more than two-fold higher relaxivity compared to currently available GdIII-based MRI contrast agents.",

author = "Luciano Lattuada and D{\'a}vid Horv{\'a}th and {Colombo Serra}, Sonia and {Fringuello Mingo}, Alberto and Paolo Minazzi and Attila B{\'e}nyei and Attila Forg{\'a}cs and Franco Fedeli and Eliana Gianolio and Silvio Aime and Giovenzana, {Giovanni B.} and Zsolt Baranyai",

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year = "2021",

month = mar,

day = "21",

doi = "10.1039/d0qi01333a",

language = "English",

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Lattuada, L, Horváth, D, Colombo Serra, S, Fringuello Mingo, A, Minazzi, P, Bényei, A, Forgács, A, Fedeli, F, Gianolio, E, Aime, S, Giovenzana, GB & Baranyai, Z 2021, 'Enhanced relaxivity of Gd^III-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange', Inorganic Chemistry Frontiers, vol. 8, n. 6, pagg. 1500-1510. https://doi.org/10.1039/d0qi01333a

Enhanced relaxivity of Gd^III-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange. / Lattuada, Luciano; Horváth, Dávid; Colombo Serra, Sonia et al.
In: Inorganic Chemistry Frontiers, Vol. 8, N. 6, 21.03.2021, pag. 1500-1510.

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

TY - JOUR

T1 - Enhanced relaxivity of GdIII-complexes with HP-DO3A-like ligands upon the activation of the intramolecular catalysis of the prototropic exchange

AU - Lattuada, Luciano

AU - Horváth, Dávid

AU - Colombo Serra, Sonia

AU - Fringuello Mingo, Alberto

AU - Minazzi, Paolo

AU - Bényei, Attila

AU - Forgács, Attila

AU - Fedeli, Franco

AU - Gianolio, Eliana

AU - Aime, Silvio

AU - Giovenzana, Giovanni B.

AU - Baranyai, Zsolt

PY - 2021/3/21

Y1 - 2021/3/21

N2 - Gadolinium(iii) complexes have been employed for more than 30 years as contrast agents in magnetic resonance imaging (MRI). In order to further improve the diagnostic accuracy of enhanced magnetic resonance images or to provide comparable enhancement at a reduced administered dose, current research is focusing on the development of GdIII-complexes characterized by higher relaxivity. In this study we describe the synthesis and the equilibrium, kinetic, relaxation and structural properties of two new GdIII-complexes based on modified 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) structure which, due to an intramolecular prototropic exchange, display more than two-fold higher relaxivity compared to currently available GdIII-based MRI contrast agents.

AB - Gadolinium(iii) complexes have been employed for more than 30 years as contrast agents in magnetic resonance imaging (MRI). In order to further improve the diagnostic accuracy of enhanced magnetic resonance images or to provide comparable enhancement at a reduced administered dose, current research is focusing on the development of GdIII-complexes characterized by higher relaxivity. In this study we describe the synthesis and the equilibrium, kinetic, relaxation and structural properties of two new GdIII-complexes based on modified 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (HP-DO3A) structure which, due to an intramolecular prototropic exchange, display more than two-fold higher relaxivity compared to currently available GdIII-based MRI contrast agents.

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