Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis

Nagisa Mori; Pekka Keski-Rahkonen; Audrey Gicquiau; Sabina Rinaldi; Niki Dimou; Sophia Harlid; Justin Harbs; Bethany Van Guelpen; Dagfinn Aune; Amanda J. Cross; Konstantinos K. Tsilidis; Gianluca Severi; Marina Kvaskoff; Agnès Fournier; Rudolf Kaaks; Renee Turzanski Fortner; Matthias B. Schulze; Paula Jakszyn; Maria Jose Sanchez; Sandra M. Colorado-Yohar; Eva Ardanaz; Ruth Travis; Eleanor L. Watts; Giovanna Masala; Vittorio Krogh; Rosario Tumino; Carlotta Sacerdote; Salvatore Panico; Bas Bueno-De-Mesquita; Inger Torhild Gram; Marit Waaseth; Marc J. Gunter; Neil Murphy

doi:10.1093/jncics/pkab084

Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis

Nagisa Mori
, Pekka Keski-Rahkonen
, Audrey Gicquiau
, Sabina Rinaldi
, Niki Dimou
, Sophia Harlid
, Justin Harbs
, Bethany Van Guelpen
, Dagfinn Aune
, Amanda J. Cross
, Konstantinos K. Tsilidis
, Gianluca Severi
, Marina Kvaskoff
, Agnès Fournier
, Rudolf Kaaks
, Renee Turzanski Fortner
, Matthias B. Schulze
, Paula Jakszyn
, Maria Jose Sanchez
, Sandra M. Colorado-Yohar

Eva Ardanaz, Ruth Travis, Eleanor L. Watts, Giovanna Masala, Vittorio Krogh, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Bas Bueno-De-Mesquita, Inger Torhild Gram, Marit Waaseth, Marc J. Gunter, Neil Murphy

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Background: Observational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results. Methods: We investigated the associations between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), progesterone, and sex hormone–binding globulin (SHBG) with colon cancer risk in a nested case-control study of 1028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were noncurrent users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to compute odds ratios and 95% confidence intervals to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided. Results: In the multivariable model, a nonstatistically significantly positive relationship was found between circulating estrone and colon cancer risk (odds ratio per log₂ 1-unit increment ¼ 1.17 [95% confidence interval ¼ 1.00 to 1.38]; odds ratio_{quartile4-quartile1} ¼ 1.33 [95% confidence interval ¼ 0.89 to 1.97], P_trend ¼ .20). Circulating concentrations of estradiol, free estradiol, testosterone, free testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the dose-response meta-analysis, no clear evidence of associations were found between circulating estradiol and estrone concentrations with colorectal, colon, and rectal cancer risk. Conclusion: Our observational and meta-analysis results do not support an association between circulating concentrations of endogenous sex hormones and colon or rectal cancer in postmenopausal women.

Lingua originale	Inglese
Numero di articolo	pkab084
Rivista	JNCI Cancer Spectrum
Volume	5
Numero di pubblicazione	6
DOI	https://doi.org/10.1093/jncics/pkab084
Stato di pubblicazione	Pubblicato - 1 dic 2021
Pubblicato esternamente	Sì

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10.1093/jncics/pkab084

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Mori, N., Keski-Rahkonen, P., Gicquiau, A., Rinaldi, S., Dimou, N., Harlid, S., Harbs, J., Van Guelpen, B., Aune, D., Cross, A. J., Tsilidis, K. K., Severi, G., Kvaskoff, M., Fournier, A., Kaaks, R., Fortner, R. T., Schulze, M. B., Jakszyn, P., Sanchez, M. J., ... Murphy, N. (2021). Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis. JNCI Cancer Spectrum, 5(6), Articolo pkab084. https://doi.org/10.1093/jncics/pkab084

@article{1bd34be774c24726868b2c06885fbe65,

title = "Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis",

abstract = "Background: Observational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results. Methods: We investigated the associations between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), progesterone, and sex hormone–binding globulin (SHBG) with colon cancer risk in a nested case-control study of 1028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were noncurrent users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to compute odds ratios and 95\% confidence intervals to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided. Results: In the multivariable model, a nonstatistically significantly positive relationship was found between circulating estrone and colon cancer risk (odds ratio per log2 1-unit increment ¼ 1.17 [95\% confidence interval ¼ 1.00 to 1.38]; odds ratioquartile4-quartile1 ¼ 1.33 [95\% confidence interval ¼ 0.89 to 1.97], Ptrend ¼ .20). Circulating concentrations of estradiol, free estradiol, testosterone, free testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the dose-response meta-analysis, no clear evidence of associations were found between circulating estradiol and estrone concentrations with colorectal, colon, and rectal cancer risk. Conclusion: Our observational and meta-analysis results do not support an association between circulating concentrations of endogenous sex hormones and colon or rectal cancer in postmenopausal women.",

author = "Nagisa Mori and Pekka Keski-Rahkonen and Audrey Gicquiau and Sabina Rinaldi and Niki Dimou and Sophia Harlid and Justin Harbs and \{Van Guelpen\}, Bethany and Dagfinn Aune and Cross, \{Amanda J.\} and Tsilidis, \{Konstantinos K.\} and Gianluca Severi and Marina Kvaskoff and Agn{\`e}s Fournier and Rudolf Kaaks and Fortner, \{Renee Turzanski\} and Schulze, \{Matthias B.\} and Paula Jakszyn and Sanchez, \{Maria Jose\} and Colorado-Yohar, \{Sandra M.\} and Eva Ardanaz and Ruth Travis and Watts, \{Eleanor L.\} and Giovanna Masala and Vittorio Krogh and Rosario Tumino and Carlotta Sacerdote and Salvatore Panico and Bas Bueno-De-Mesquita and Gram, \{Inger Torhild\} and Marit Waaseth and Gunter, \{Marc J.\} and Neil Murphy",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press.",

year = "2021",

month = dec,

day = "1",

doi = "10.1093/jncics/pkab084",

language = "English",

volume = "5",

journal = "JNCI Cancer Spectrum",

issn = "2515-5091",

publisher = "Oxford University Press",

number = "6",

}

Mori, N, Keski-Rahkonen, P, Gicquiau, A, Rinaldi, S, Dimou, N, Harlid, S, Harbs, J, Van Guelpen, B, Aune, D, Cross, AJ, Tsilidis, KK, Severi, G, Kvaskoff, M, Fournier, A, Kaaks, R, Fortner, RT, Schulze, MB, Jakszyn, P, Sanchez, MJ, Colorado-Yohar, SM, Ardanaz, E, Travis, R, Watts, EL, Masala, G, Krogh, V, Tumino, R, Sacerdote, C, Panico, S, Bueno-De-Mesquita, B, Gram, IT, Waaseth, M, Gunter, MJ & Murphy, N 2021, 'Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis', JNCI Cancer Spectrum, vol. 5, n. 6, pkab084. https://doi.org/10.1093/jncics/pkab084

TY - JOUR

T1 - Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women

T2 - A Prospective Study and Meta-Analysis

AU - Mori, Nagisa

AU - Keski-Rahkonen, Pekka

AU - Gicquiau, Audrey

AU - Rinaldi, Sabina

AU - Dimou, Niki

AU - Harlid, Sophia

AU - Harbs, Justin

AU - Van Guelpen, Bethany

AU - Aune, Dagfinn

AU - Cross, Amanda J.

AU - Tsilidis, Konstantinos K.

AU - Severi, Gianluca

AU - Kvaskoff, Marina

AU - Fournier, Agnès

AU - Kaaks, Rudolf

AU - Fortner, Renee Turzanski

AU - Schulze, Matthias B.

AU - Jakszyn, Paula

AU - Sanchez, Maria Jose

AU - Colorado-Yohar, Sandra M.

AU - Ardanaz, Eva

AU - Travis, Ruth

AU - Watts, Eleanor L.

AU - Masala, Giovanna

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Panico, Salvatore

AU - Bueno-De-Mesquita, Bas

AU - Gram, Inger Torhild

AU - Waaseth, Marit

AU - Gunter, Marc J.

AU - Murphy, Neil

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Background: Observational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results. Methods: We investigated the associations between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), progesterone, and sex hormone–binding globulin (SHBG) with colon cancer risk in a nested case-control study of 1028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were noncurrent users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to compute odds ratios and 95% confidence intervals to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided. Results: In the multivariable model, a nonstatistically significantly positive relationship was found between circulating estrone and colon cancer risk (odds ratio per log2 1-unit increment ¼ 1.17 [95% confidence interval ¼ 1.00 to 1.38]; odds ratioquartile4-quartile1 ¼ 1.33 [95% confidence interval ¼ 0.89 to 1.97], Ptrend ¼ .20). Circulating concentrations of estradiol, free estradiol, testosterone, free testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the dose-response meta-analysis, no clear evidence of associations were found between circulating estradiol and estrone concentrations with colorectal, colon, and rectal cancer risk. Conclusion: Our observational and meta-analysis results do not support an association between circulating concentrations of endogenous sex hormones and colon or rectal cancer in postmenopausal women.

AB - Background: Observational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results. Methods: We investigated the associations between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), progesterone, and sex hormone–binding globulin (SHBG) with colon cancer risk in a nested case-control study of 1028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were noncurrent users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to compute odds ratios and 95% confidence intervals to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided. Results: In the multivariable model, a nonstatistically significantly positive relationship was found between circulating estrone and colon cancer risk (odds ratio per log2 1-unit increment ¼ 1.17 [95% confidence interval ¼ 1.00 to 1.38]; odds ratioquartile4-quartile1 ¼ 1.33 [95% confidence interval ¼ 0.89 to 1.97], Ptrend ¼ .20). Circulating concentrations of estradiol, free estradiol, testosterone, free testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the dose-response meta-analysis, no clear evidence of associations were found between circulating estradiol and estrone concentrations with colorectal, colon, and rectal cancer risk. Conclusion: Our observational and meta-analysis results do not support an association between circulating concentrations of endogenous sex hormones and colon or rectal cancer in postmenopausal women.

UR - https://www.scopus.com/pages/publications/85126288006

U2 - 10.1093/jncics/pkab084

DO - 10.1093/jncics/pkab084

M3 - Article

SN - 2515-5091

VL - 5

JO - JNCI Cancer Spectrum

JF - JNCI Cancer Spectrum

IS - 6

M1 - pkab084

ER -

Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis

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