TY - JOUR
T1 - Elevated serum levels of osteopontin in HCV-associated lymphoproliferative disorders
AU - Libra, Massimo
AU - Indelicato, Manuela
AU - De Re, Valli
AU - Zignego, Anna Linda
AU - Chiocchetti, Annalisa
AU - Malaponte, Grazia
AU - Dianzani, Umberto
AU - Nicoletti, Ferdinando
AU - Stivala, Franca
AU - McCubrey, James A.
AU - Mazzarino, Maria C.
N1 - Funding Information:
To determine whether changes in OPN levels were associated with HCV infection, type II MC syndrome, or B-cell NHL, we compared serum OPN levels in HCV-infected patients affected by type II MC syndrome, B cell NHL either singly or in combination. Serum OPN levels of B-cell NHL patients without HCV infection, HCV-infected patients free from either type II MC syndrome or B-cell NHL and healthy donors were The authors thank Jerry Polesel for assisting also analyzed. with statistical analysis. This work was partially Research (AIRC); by COFIN MIUR, Italy; J.A.M.supported by Italian Association for Cancer PATIENTS AND METHODS
PY - 2005/11
Y1 - 2005/11
N2 - Hepatitis C virus (HCV) infection is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Recent evidences have also suggested that HCV infection contributes to development of autoimmune disorders and B-cell nonHodgkin's lymphoma (NHL). Mechanisms by which HCV infection promotes B-cell NHL development remain unclear. Increased serum osteopontin (OPN) levels have been associated with several autoimmune diseases as well as a variety of cancers. However, the association between OPN and B-cell NHL or HCV-associated B-cell proliferation has not previously been reported. In the present study, we determined whether serum OPN differences were associated with HCV infection, type II mixed cryglobulinemia (MC) syndrome and B-cell NHL. Serum OPN levels were measured by capture enzyme-linked immunosorbent assay. Our results show that high serum OPN levels are associated with B-cell NHL and HCV infection. Interestingly, highest serum OPN concentrations were found among HCV-infected patients with concomitant type II MC syndrome with and without B-cell NHL. These data indicate that OPN is involved in the lymphomagenesis, especially, in the context of HCV infection and autoimmune diseases.
AB - Hepatitis C virus (HCV) infection is associated with chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Recent evidences have also suggested that HCV infection contributes to development of autoimmune disorders and B-cell nonHodgkin's lymphoma (NHL). Mechanisms by which HCV infection promotes B-cell NHL development remain unclear. Increased serum osteopontin (OPN) levels have been associated with several autoimmune diseases as well as a variety of cancers. However, the association between OPN and B-cell NHL or HCV-associated B-cell proliferation has not previously been reported. In the present study, we determined whether serum OPN differences were associated with HCV infection, type II mixed cryglobulinemia (MC) syndrome and B-cell NHL. Serum OPN levels were measured by capture enzyme-linked immunosorbent assay. Our results show that high serum OPN levels are associated with B-cell NHL and HCV infection. Interestingly, highest serum OPN concentrations were found among HCV-infected patients with concomitant type II MC syndrome with and without B-cell NHL. These data indicate that OPN is involved in the lymphomagenesis, especially, in the context of HCV infection and autoimmune diseases.
KW - HCV
KW - NHL
KW - Ostepontin
KW - Type II mixed cryoglobulinemia syndrome
UR - https://www.scopus.com/pages/publications/33646426905
U2 - 10.4161/cbt.4.11.2087
DO - 10.4161/cbt.4.11.2087
M3 - Article
SN - 1538-4047
VL - 4
SP - 1192
EP - 1194
JO - Cancer Biology and Therapy
JF - Cancer Biology and Therapy
IS - 11
ER -
