Electronic effects of the substituents on relaxometric and CEST behaviour of Ln(III)-DOTA-tetraanilides

Valeria Lagostina, Loredana Leone, Fabio Carniato, Giuseppe Digilio, Lorenzo Tei, Mauro Botta

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Three different 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide (DOTAM) derivatives bearing as amide N-substituents phenyl, p-methoxyphenyl and p-ethylbenzoate groups were synthesized and the 1H and 17O NMR relaxometric behaviour of the Gd(III)-chelates and chemical exchange saturation transfer (CEST) effect of the Eu(III) complexes were evaluated. The electronic properties of the substituents were shown to strongly influence the coordinated water exchange rate (kex), resulting in five times faster kex for the electron donating phenylmethoxy group compared to the electron withdrawing ethylbenzoate group.

Lingua originaleInglese
Numero di articolo43
RivistaInorganics
Volume7
Numero di pubblicazione4
DOI
Stato di pubblicazionePubblicato - 1 apr 2019

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