Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Riccardo Mossetti; Tracey Pirall; Gian Cesare Tron; Jieping Zhu

doi:10.1021/ol902894p

Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Riccardo Mossetti, Tracey Pirall, Gian Cesare Tron, Jieping Zhu

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

"Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

Lingua originale	Inglese
pagine (da-a)	820-823
Numero di pagine	4
Rivista	Organic Letters
Volume	12
Numero di pubblicazione	4
DOI	https://doi.org/10.1021/ol902894p
Stato di pubblicazione	Pubblicato - 19 feb 2010

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10.1021/ol902894p

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title = "Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides",

abstract = "{"}Chemical equation presented{"} Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.",

author = "Riccardo Mossetti and Tracey Pirall and Tron, \{Gian Cesare\} and Jieping Zhu",

year = "2010",

month = feb,

day = "19",

doi = "10.1021/ol902894p",

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pages = "820--823",

journal = "Organic Letters",

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T1 - Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

AU - Mossetti, Riccardo

AU - Pirall, Tracey

AU - Tron, Gian Cesare

AU - Zhu, Jieping

PY - 2010/2/19

Y1 - 2010/2/19

N2 - "Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

AB - "Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

UR - https://www.scopus.com/pages/publications/76849113146

U2 - 10.1021/ol902894p

DO - 10.1021/ol902894p

M3 - Article

SN - 1523-7060

VL - 12

SP - 820

EP - 823

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Abstract

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