Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Riccardo Mossetti; Tracey Pirall; Gian Cesare Tron; Jieping Zhu

doi:10.1021/ol902894p

Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Riccardo Mossetti, Tracey Pirall, Gian Cesare Tron, Jieping Zhu

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

"Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

Lingua originale	Inglese
pagine (da-a)	820-823
Numero di pagine	4
Rivista	Organic Letters
Volume	12
Numero di pubblicazione	4
DOI	https://doi.org/10.1021/ol902894p
Stato di pubblicazione	Pubblicato - 19 feb 2010

Accesso al documento

10.1021/ol902894p

Altri file e collegamenti

Link to publication in Scopus

Cita questo

@article{cad5d76c0113435e9e3efc1add82555a,

title = "Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides",

abstract = "{"}Chemical equation presented{"} Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.",

author = "Riccardo Mossetti and Tracey Pirall and Tron, {Gian Cesare} and Jieping Zhu",

year = "2010",

month = feb,

day = "19",

doi = "10.1021/ol902894p",

language = "English",

volume = "12",

pages = "820--823",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

AU - Mossetti, Riccardo

AU - Pirall, Tracey

AU - Tron, Gian Cesare

AU - Zhu, Jieping

PY - 2010/2/19

Y1 - 2010/2/19

N2 - "Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

AB - "Chemical equation presented" Acyl chlorides and α-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to α-ketoamides in good overall yields.

UR - http://www.scopus.com/inward/record.url?scp=76849113146&partnerID=8YFLogxK

U2 - 10.1021/ol902894p

DO - 10.1021/ol902894p

M3 - Article

SN - 1523-7060

VL - 12

SP - 820

EP - 823

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Efficient synthesis of α-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and α-isocyanoacetamides

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo