TY - JOUR
T1 - Effects of TRH-T on spinal motoneurones in man
AU - Raffaele, Rocco
AU - Cosentino, Emanuele
AU - Anicito, Maria B.
AU - Sciacca, Alfio
AU - Rampello, Liborio
AU - Pennisi, Giovanni
AU - Genazzani, Armando A.
AU - Bosco, Gianfranco
AU - Casabona, Antonino
AU - Drago, Filippo
PY - 1992/11
Y1 - 1992/11
N2 - The effect of thyrotropin-releasing hormone tartrate (TRH-T) on the decrease in H Max/M Max ratio, an index of the spinal motoneurone pool, induced by haloperidol, was studied in 15 healthy volunteers. In all subjects, the H response was examined by an electromyographic apparatus. The values were expressed as H Max/M Max ratio, that gives an index of excitability of the spinal motoneurone pool. It was found that the mean H Max/M Max ratio value significantly decreased after haloperidol administration, but this effect was completely reversed by the injection of TRH-T. This finding suggests that the peptide may modulate motoneurone functions.
AB - The effect of thyrotropin-releasing hormone tartrate (TRH-T) on the decrease in H Max/M Max ratio, an index of the spinal motoneurone pool, induced by haloperidol, was studied in 15 healthy volunteers. In all subjects, the H response was examined by an electromyographic apparatus. The values were expressed as H Max/M Max ratio, that gives an index of excitability of the spinal motoneurone pool. It was found that the mean H Max/M Max ratio value significantly decreased after haloperidol administration, but this effect was completely reversed by the injection of TRH-T. This finding suggests that the peptide may modulate motoneurone functions.
KW - Haloperidol
KW - Spinal motoneurone pool
KW - Thyrotropin-releasing hormone
UR - http://www.scopus.com/inward/record.url?scp=0026441547&partnerID=8YFLogxK
U2 - 10.1097/00001756-199211000-00018
DO - 10.1097/00001756-199211000-00018
M3 - Article
SN - 0959-4965
VL - 3
SP - 1017
EP - 1018
JO - NeuroReport
JF - NeuroReport
IS - 11
ER -