Effects of some typical and atypical antidepressants on GAD activity in various brain regions

L. Rampello; F. Patti; F. Condorelli; A. Reggio; A. Prato; P. L. Canonico; F. Nicoletti

Effects of some typical and atypical antidepressants on GAD activity in various brain regions

L. Rampello
, F. Patti
, F. Condorelli
, A. Reggio
, A. Prato
, P. L. Canonico
, F. Nicoletti

Dipartimento di Scienze del Farmaco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

Lingua originale	Inglese
pagine (da-a)	89-94
Numero di pagine	6
Rivista	L'Encephale
Volume	8
Numero di pubblicazione	1
Stato di pubblicazione	Pubblicato - 1982

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title = "Effects of some typical and atypical antidepressants on GAD activity in various brain regions",

abstract = "The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.",

author = "L. Rampello and F. Patti and F. Condorelli and A. Reggio and A. Prato and Canonico, \{P. L.\} and F. Nicoletti",

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AU - Rampello, L.

AU - Patti, F.

AU - Condorelli, F.

AU - Reggio, A.

AU - Prato, A.

AU - Canonico, P. L.

AU - Nicoletti, F.

PY - 1982

Y1 - 1982

N2 - The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

AB - The authors have investigated the effects of acute or chronic injection of typical and atypical antidepressants on the activity of the GABA-synthesizing enzyme glutamic acid decarboxylase (GAD, EC 4.1.1.15) in discrete brain regions. Very significant changes in GAD activity were observed only with sulpiride and nomifensine, two atypical antidepressants that selectively influence dopaminergic transmission and, in turn, prolactin secretion.

UR - https://www.scopus.com/pages/publications/0020070620

M3 - Article

SN - 0013-7006

VL - 8

SP - 89

EP - 94

JO - L'Encephale

JF - L'Encephale

IS - 1

ER -

Effects of some typical and atypical antidepressants on GAD activity in various brain regions

Abstract

OSS delle Nazioni Unite

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