Effects of some experimental factors on the production process of solid lipid nanoparticles

R. Cavalli; E. Marengo; L. Rodriguez; M. R. Gasco

Effects of some experimental factors on the production process of solid lipid nanoparticles

R. Cavalli, E. Marengo, L. Rodriguez, M. R. Gasco

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A simple device to form solid lipid nanoparticles from warm O/W microemulsions was developed. Precise control of temperature, drop dimensions and delivery rate of the microemulsion was achieved, obtaining reproducible nanoparticle dispersions. Experimental design was applied to study the effect of five experimental factors on the average diameter and size distribution of the lipid nanoparticles obtained from three different microemulsions. The results showed that the five experimental parameters as well as the microemulsion composition affected the average diameter and size distribution of solid lipid nanoparticles.

Lingua originale	Inglese
pagine (da-a)	110-115
Numero di pagine	6
Rivista	European Journal of Pharmaceutics and Biopharmaceutics
Volume	42
Numero di pubblicazione	2
Stato di pubblicazione	Pubblicato - 1996
Pubblicato esternamente	Sì

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title = "Effects of some experimental factors on the production process of solid lipid nanoparticles",

abstract = "A simple device to form solid lipid nanoparticles from warm O/W microemulsions was developed. Precise control of temperature, drop dimensions and delivery rate of the microemulsion was achieved, obtaining reproducible nanoparticle dispersions. Experimental design was applied to study the effect of five experimental factors on the average diameter and size distribution of the lipid nanoparticles obtained from three different microemulsions. The results showed that the five experimental parameters as well as the microemulsion composition affected the average diameter and size distribution of solid lipid nanoparticles.",

keywords = "O/W microemulsions, average diameter, factorial design, preparation device, solid colloidal carrier, solid lipid nanoparticles optimization",

author = "R. Cavalli and E. Marengo and L. Rodriguez and Gasco, {M. R.}",

year = "1996",

language = "English",

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T1 - Effects of some experimental factors on the production process of solid lipid nanoparticles

AU - Cavalli, R.

AU - Marengo, E.

AU - Rodriguez, L.

AU - Gasco, M. R.

PY - 1996

Y1 - 1996

N2 - A simple device to form solid lipid nanoparticles from warm O/W microemulsions was developed. Precise control of temperature, drop dimensions and delivery rate of the microemulsion was achieved, obtaining reproducible nanoparticle dispersions. Experimental design was applied to study the effect of five experimental factors on the average diameter and size distribution of the lipid nanoparticles obtained from three different microemulsions. The results showed that the five experimental parameters as well as the microemulsion composition affected the average diameter and size distribution of solid lipid nanoparticles.

AB - A simple device to form solid lipid nanoparticles from warm O/W microemulsions was developed. Precise control of temperature, drop dimensions and delivery rate of the microemulsion was achieved, obtaining reproducible nanoparticle dispersions. Experimental design was applied to study the effect of five experimental factors on the average diameter and size distribution of the lipid nanoparticles obtained from three different microemulsions. The results showed that the five experimental parameters as well as the microemulsion composition affected the average diameter and size distribution of solid lipid nanoparticles.

KW - O/W microemulsions

KW - average diameter

KW - factorial design

KW - preparation device

KW - solid colloidal carrier

KW - solid lipid nanoparticles optimization

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M3 - Article

SN - 0939-6411

VL - 42

SP - 110

EP - 115

JO - European Journal of Pharmaceutics and Biopharmaceutics

JF - European Journal of Pharmaceutics and Biopharmaceutics

IS - 2

ER -

Effects of some experimental factors on the production process of solid lipid nanoparticles

Abstract

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