Abstract
We investigated the effects of ethinyl estradiol (5 mg/kg body wt daily for 5 days, orally) and/or iron sorbitol (50 mg/kg body wt daily for 5 days, i.m.) on bile flow, bile salt independent fraction (BSIF), hepatic ∂-amino-levulinate synthase (ALA-S) and uroporphyrinogen decarboxylase (URO-D) in female rats. Ethinyl estradiol administration was associated with a significant decrease of bile flow and BSIF and an increase in URO-D activity in comparison to control values. Iron alone did not modify biliary parameters, but significantly increased the activity of ALA-S. Combined treatment with ethinyl extradiol plus iron partially corrected the reduction of BSIF and restored the activity of ALA-S and URO-D to control levels. Thus iron appears to exert a partially protective effect against ethinyl estradiol-induced cholestasis. No porphyrinogenic effect was observed.
Lingua originale | Inglese |
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pagine (da-a) | 187-196 |
Numero di pagine | 10 |
Rivista | Toxicology |
Volume | 38 |
Numero di pubblicazione | 2 |
DOI | |
Stato di pubblicazione | Pubblicato - feb 1986 |
Pubblicato esternamente | Sì |