Effects of iron overload on bile secretion and hepatic porphyrin metabolism in ethinyl extradiol-treated rats

L. Cantoni, C. Dui Padova, M. Rizzardini, D. Dal Fiume, A. Graziani, P. Rovagnati, R. Tritapepe

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

We investigated the effects of ethinyl estradiol (5 mg/kg body wt daily for 5 days, orally) and/or iron sorbitol (50 mg/kg body wt daily for 5 days, i.m.) on bile flow, bile salt independent fraction (BSIF), hepatic ∂-amino-levulinate synthase (ALA-S) and uroporphyrinogen decarboxylase (URO-D) in female rats. Ethinyl estradiol administration was associated with a significant decrease of bile flow and BSIF and an increase in URO-D activity in comparison to control values. Iron alone did not modify biliary parameters, but significantly increased the activity of ALA-S. Combined treatment with ethinyl extradiol plus iron partially corrected the reduction of BSIF and restored the activity of ALA-S and URO-D to control levels. Thus iron appears to exert a partially protective effect against ethinyl estradiol-induced cholestasis. No porphyrinogenic effect was observed.

Lingua originaleInglese
pagine (da-a)187-196
Numero di pagine10
RivistaToxicology
Volume38
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - feb 1986
Pubblicato esternamente

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