Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

Ferdinando Nicoletti; G. Dementi; A. Prato; P. L. Canonico; L. Rampello; F. Patti; R. M. Di Giorgio; U. Scapagnini

doi:10.1159/000123430

Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

Ferdinando Nicoletti, G. Dementi, A. Prato, P. L. Canonico, L. Rampello, F. Patti, R. M. Di Giorgio, U. Scapagnini

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.

Lingua originale	Inglese
pagine (da-a)	13-16
Numero di pagine	4
Rivista	Neuroendocrinology
Volume	36
Numero di pubblicazione	1
DOI	https://doi.org/10.1159/000123430
Stato di pubblicazione	Pubblicato - 1983
Pubblicato esternamente	Sì

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title = "Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat",

abstract = "Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.",

keywords = "Glutamic acid decarboxylase, Medial basal hypothalamus, Prolactin",

author = "Ferdinando Nicoletti and G. Dementi and A. Prato and Canonico, {P. L.} and L. Rampello and F. Patti and {Di Giorgio}, {R. M.} and U. Scapagnini",

year = "1983",

doi = "10.1159/000123430",

language = "English",

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T1 - Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

AU - Nicoletti, Ferdinando

AU - Dementi, G.

AU - Prato, A.

AU - Canonico, P. L.

AU - Rampello, L.

AU - Patti, F.

AU - Di Giorgio, R. M.

AU - Scapagnini, U.

PY - 1983

Y1 - 1983

N2 - Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.

AB - Haloperidol, sulpiride, domperidone and apomorphine, drugs which influence dopamine (DA) receptors and in turn prolactin (PRL) secretion have been shown to induce parallel changes in medial basal hypothalamic (MBH) glutamate decarboxylase (GAD) activity and serum PRL levels. The possibility that PRL may be involved in the effects of the drugs on MBH GAD activity is suggested in view of the evidence that hypophysectomy completely prevents drug-induced MBH GAD activity changes and that hyperprolactinemia by anterior pituitary homograft results in a significant, although small, change in the enzymatic activity.

KW - Glutamic acid decarboxylase

KW - Medial basal hypothalamus

KW - Prolactin

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U2 - 10.1159/000123430

DO - 10.1159/000123430

M3 - Article

SN - 0028-3835

VL - 36

SP - 13

EP - 16

JO - Neuroendocrinology

JF - Neuroendocrinology

IS - 1

ER -

Effects of hyper- and hypoprolactinemia on glutamate decarboxylase activity in medial basal hypothalamus of male rat

Abstract

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