Effects of continuing or stopping exposure to risk factors on natural history of laryngeal precancerous lesions

G. Succo, G. Valente, F. Riva, P. Gabriele, C. F. Gervasio, M. Airoldi, R. Ragona, G. Cortesina, A. Sartorisi

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Background. The process of laryngeal carcinogenesis often develops through quite slow steps (precancerous lesions) and is influenced by various risk factors, the most important being tobacco smoke and alcohol consumption. Methods. In this study (including 216 men) we wanted to investigate wether continuing or stopping exposure to tobacco smoke and alcohol consumption would modify the natural history of such lesions in patients not treated other than by decortication of the true vocal cords for precancerous lesions, classified in accordance with the scale recommended by Hellquist: class 1 (mild dysplasia), class 2 (moderate dysplasia), class 3 (severe dysplasia - carcinoma in situ). Results. In all 3 classes; the differences of clinical evolution between patients who stopped exposure to such risk factors after first decortication and patients who did not stop, was statistically significant with no evidence of disease at 60 months in 90.3% and 47.3% of cases respectively Conclusions. We have noted a statistically significant correlation between exposition to smoking plus alcohol and class of dysplasia and between class of dysplasia and risk of recurrence and progression into invasive carcinoma.

Lingua originaleInglese
pagine (da-a)20-24
Numero di pagine5
RivistaCancer Journal
Volume7
Numero di pubblicazione1
Stato di pubblicazionePubblicato - 1994
Pubblicato esternamente

Fingerprint

Entra nei temi di ricerca di 'Effects of continuing or stopping exposure to risk factors on natural history of laryngeal precancerous lesions'. Insieme formano una fingerprint unica.

Cita questo