Effects of calcitonin on rat extrapyramidal motor system: behavioral and biochemical data

Ferdinando Nicoletti; Giuseppe Clementi; Francesco Patti; Pier Luigi Canonico; Rosa Maria di Giorgio; Mario Matera; Giovanni Pennisi; Luciano Angelucci; Umberto Scapagnini

doi:10.1016/0006-8993(82)90436-X

Effects of calcitonin on rat extrapyramidal motor system: behavioral and biochemical data

Ferdinando Nicoletti, Giuseppe Clementi, Francesco Patti, Pier Luigi Canonico, Rosa Maria di Giorgio, Mario Matera, Giovanni Pennisi, Luciano Angelucci, Umberto Scapagnini

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

The effects of i.v.c. injection of human and salmon calcitonin on biochemical and behavioral parameters related to the extrapyramidal motor system, were investigated in male rats. Calcitonin injection resulted in a potentiation of haloperidol-induced catalepsy and a partial prevention of apomorphine-induced hyperactivity. Moreover calcitonin induced a significant decrease in nigral GAD activity but no change in striatal DA and DOPAC concentration or GAD activity. The results are discussed in view of a primary action of calcitonin on the striatonigral GABAergic pathway mediating the DA-related behavioral messages of striatal origin.

Lingua originale	Inglese
pagine (da-a)	381-385
Numero di pagine	5
Rivista	Brain Research
Volume	250
Numero di pubblicazione	2
DOI	https://doi.org/10.1016/0006-8993(82)90436-X
Stato di pubblicazione	Pubblicato - 4 nov 1982
Pubblicato esternamente	Sì

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10.1016/0006-8993(82)90436-X

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title = "Effects of calcitonin on rat extrapyramidal motor system: behavioral and biochemical data",

abstract = "The effects of i.v.c. injection of human and salmon calcitonin on biochemical and behavioral parameters related to the extrapyramidal motor system, were investigated in male rats. Calcitonin injection resulted in a potentiation of haloperidol-induced catalepsy and a partial prevention of apomorphine-induced hyperactivity. Moreover calcitonin induced a significant decrease in nigral GAD activity but no change in striatal DA and DOPAC concentration or GAD activity. The results are discussed in view of a primary action of calcitonin on the striatonigral GABAergic pathway mediating the DA-related behavioral messages of striatal origin.",

keywords = "DA/DOPAC, GAD, calcitonin, catalepsy, corpus striatum, hyperactivity, substantia nigra",

author = "Ferdinando Nicoletti and Giuseppe Clementi and Francesco Patti and Canonico, \{Pier Luigi\} and \{di Giorgio\}, \{Rosa Maria\} and Mario Matera and Giovanni Pennisi and Luciano Angelucci and Umberto Scapagnini",

year = "1982",

month = nov,

day = "4",

doi = "10.1016/0006-8993(82)90436-X",

language = "English",

volume = "250",

pages = "381--385",

journal = "Brain Research",

issn = "0006-8993",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Effects of calcitonin on rat extrapyramidal motor system

T2 - behavioral and biochemical data

AU - Nicoletti, Ferdinando

AU - Clementi, Giuseppe

AU - Patti, Francesco

AU - Canonico, Pier Luigi

AU - di Giorgio, Rosa Maria

AU - Matera, Mario

AU - Pennisi, Giovanni

AU - Angelucci, Luciano

AU - Scapagnini, Umberto

PY - 1982/11/4

Y1 - 1982/11/4

N2 - The effects of i.v.c. injection of human and salmon calcitonin on biochemical and behavioral parameters related to the extrapyramidal motor system, were investigated in male rats. Calcitonin injection resulted in a potentiation of haloperidol-induced catalepsy and a partial prevention of apomorphine-induced hyperactivity. Moreover calcitonin induced a significant decrease in nigral GAD activity but no change in striatal DA and DOPAC concentration or GAD activity. The results are discussed in view of a primary action of calcitonin on the striatonigral GABAergic pathway mediating the DA-related behavioral messages of striatal origin.

AB - The effects of i.v.c. injection of human and salmon calcitonin on biochemical and behavioral parameters related to the extrapyramidal motor system, were investigated in male rats. Calcitonin injection resulted in a potentiation of haloperidol-induced catalepsy and a partial prevention of apomorphine-induced hyperactivity. Moreover calcitonin induced a significant decrease in nigral GAD activity but no change in striatal DA and DOPAC concentration or GAD activity. The results are discussed in view of a primary action of calcitonin on the striatonigral GABAergic pathway mediating the DA-related behavioral messages of striatal origin.

KW - DA/DOPAC

KW - GAD

KW - calcitonin

KW - catalepsy

KW - corpus striatum

KW - hyperactivity

KW - substantia nigra

UR - https://www.scopus.com/pages/publications/0019904866

U2 - 10.1016/0006-8993(82)90436-X

DO - 10.1016/0006-8993(82)90436-X

M3 - Article

SN - 0006-8993

VL - 250

SP - 381

EP - 385

JO - Brain Research

JF - Brain Research

IS - 2

ER -

Effects of calcitonin on rat extrapyramidal motor system: behavioral and biochemical data

Abstract

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