TY - JOUR
T1 - Effect of red wine antioxidants and minor polyphenolic constituents on endothelial progenitor cells after physical training in mice
AU - Balestrieri, Maria Luisa
AU - Fiorito, Carmela
AU - Crimi, Ettore
AU - Felice, Francesca
AU - Schiano, Concetta
AU - Milone, Lara
AU - Casamassimi, Amelia
AU - Giovane, Alfonso
AU - Grimaldi, Vincenzo
AU - del Giudice, Vincenzo
AU - Minucci, Pellegrino Biagio
AU - Mancini, Francesco Paolo
AU - Servillo, Luigi
AU - D'Armiento, Francesco Paolo
AU - Farzati, Bartolomeo
AU - Napoli, Claudio
N1 - Funding Information:
This work was supported in part by a grant from Regione Campania legge 5 2006 code BRC1498 “Effetti in vivo ed in vitro dei polifenoli del vino rosso da diverse viticolture sull'espressione genica endoteliale durante lo shear stress perturbato e loro relazione con i processi biotecnologici della produzione del vino” (M.L.B. and C.N.), an unrestricted grant from Feudi di San Gregorio (C.N.), by PRIN MIUR 2006 code 0622153_002 “Meccanismi fisiopatologici di danno vascolare/trombotico e angiogenesis”(C.N) and by Fondation Jerome Lejeune (C.N.).
PY - 2008/5/23
Y1 - 2008/5/23
N2 - Circulating endothelial progenitor cells (EPCs) play a significant role in regeneration of damaged blood vessels. Levels and functional activities of EPCs are noticeable altered by risk factors for coronary heart disease (CHD) and compounds that can prevent or ameliorate EPC dysfunction are currently of special clinical interest. Here, we evaluate the effects of red wine (RW) on EPCs in C57BL/6J mice subjected to physical exercise. FACS computed counting showed a significant increase of EPC number (P < 0.05) in mice after short-term supplementation with RW. VEGF serum concentration was significantly increased by physical training in the presence or absence of RW supplementation (P < 0.001). These in vivo observations support previous in vitro observation of the beneficial effect of RW in the modulation of EPC levels.
AB - Circulating endothelial progenitor cells (EPCs) play a significant role in regeneration of damaged blood vessels. Levels and functional activities of EPCs are noticeable altered by risk factors for coronary heart disease (CHD) and compounds that can prevent or ameliorate EPC dysfunction are currently of special clinical interest. Here, we evaluate the effects of red wine (RW) on EPCs in C57BL/6J mice subjected to physical exercise. FACS computed counting showed a significant increase of EPC number (P < 0.05) in mice after short-term supplementation with RW. VEGF serum concentration was significantly increased by physical training in the presence or absence of RW supplementation (P < 0.001). These in vivo observations support previous in vitro observation of the beneficial effect of RW in the modulation of EPC levels.
KW - Antioxidants
KW - Endothelial progenitor cells
KW - Physical exercise
KW - Red wine
UR - http://www.scopus.com/inward/record.url?scp=42649092117&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2007.11.081
DO - 10.1016/j.ijcard.2007.11.081
M3 - Article
SN - 0167-5273
VL - 126
SP - 295
EP - 297
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 2
ER -