Effect of Lactobacillus GG supplementation on pulmonary exacerbations in patients with cystic fibrosis: A pilot study

Eugenia Bruzzese, Valeria Raia, Maria Immacolata Spagnuolo, Monica Volpicelli, Giulio De Marco, Luigi Maiuri, Alfredo Guarino

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

Background & aims: Probiotics reduce intestinal inflammation in children with cystic fibrosis (CF). We want to determine the effects of Lactobacillus GG (LGG) on pulmonary exacerbations in CF. Methods: A prospective, randomized, placebo-controlled, cross-over study was performed. Nineteen children received LGG for 6 months and then shifted to oral rehydration solution (ORS) for 6 months. In parallel nineteen received ORS and then shifted to LGG. Main outcome parameters were: incidence of pulmonary exacerbations and of hospital admissions, forced expiratory volume (FEV1), and modifications of body weight. Results: Patients treated with LGG showed a reduction of pulmonary exacerbations (Median 1 vs. 2, range 4 vs. 4, median difference 1, CI 95% 0.5-1.5; p=0.0035) and of hospital admissions (Median 0 vs. 1, range 3 vs. 2, median difference 1, CI95% 1.0-1.5; p=0.001) compared to patients treated with ORS. LGG resulted in a greater increase in FEV1 (3.6%±5.2 vs. 0.9%±5; p=0.02) and body weight (1.5 kg±1.8 vs. 0.7 kg±1.8; p=0.02). Conclusions: LGG reduces pulmonary exacerbations and hospital admissions in patients with CF. These suggest that probiotics may delay respiratory impairment and that a relationship exists between intestinal and pulmonary inflammation.

Lingua originaleInglese
pagine (da-a)322-328
Numero di pagine7
RivistaClinical Nutrition
Volume26
Numero di pubblicazione3
DOI
Stato di pubblicazionePubblicato - giu 2007
Pubblicato esternamente

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