Effect of dihydroergocryptine and dihydroergocristine on cyclic amp accumulation and prolactin release in vitro: Evidence for a dopaminomimetic action

Lucia Fiore; Umberto Scapagnini; Pier Luigi Canonico

doi:10.1159/000180649

Effect of dihydroergocryptine and dihydroergocristine on cyclic amp accumulation and prolactin release in vitro: Evidence for a dopaminomimetic action

Lucia Fiore
, Umberto Scapagnini
, Pier Luigi Canonico

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Dihydroergocryptine and dihydroergocristine, two C-9, 10-hydrogenated ergot alkaloids, inhibited in a concentration-dependent manner prolactin release and cyclic AMP accumulation in cultured anterior pituitary cells. The inhibitory effect of dihydroergocryptine was more potent and started at lower concentrations than that of dihydroergocristine. Haloperidol and pimozide, two dopamine receptor antagonists, completely abolished the inhibitory activity of the ergot alkaloids. The involvement of the adenylate cyclase-cyclic AMP system in the inhibitory action of the two compounds was demonstrated by the antagonism by pertussis toxin of the reduction of both prolactin release and cyclic AMP accumulation produced by dihydroergocryptine and dihydroergocristine.

Lingua originale	Inglese
pagine (da-a)	171-177
Numero di pagine	7
Rivista	Hormone Research in Paediatrics
Volume	25
Numero di pubblicazione	3
DOI	https://doi.org/10.1159/000180649
Stato di pubblicazione	Pubblicato - 1987
Pubblicato esternamente	Sì

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title = "Effect of dihydroergocryptine and dihydroergocristine on cyclic amp accumulation and prolactin release in vitro: Evidence for a dopaminomimetic action",

abstract = "Dihydroergocryptine and dihydroergocristine, two C-9, 10-hydrogenated ergot alkaloids, inhibited in a concentration-dependent manner prolactin release and cyclic AMP accumulation in cultured anterior pituitary cells. The inhibitory effect of dihydroergocryptine was more potent and started at lower concentrations than that of dihydroergocristine. Haloperidol and pimozide, two dopamine receptor antagonists, completely abolished the inhibitory activity of the ergot alkaloids. The involvement of the adenylate cyclase-cyclic AMP system in the inhibitory action of the two compounds was demonstrated by the antagonism by pertussis toxin of the reduction of both prolactin release and cyclic AMP accumulation produced by dihydroergocryptine and dihydroergocristine.",

keywords = "Cyclic AMP, Dihydroergocristine, Dihydroergocryptine, Pertussis toxin, Prolactin",

author = "Lucia Fiore and Umberto Scapagnini and Canonico, \{Pier Luigi\}",

year = "1987",

doi = "10.1159/000180649",

language = "English",

volume = "25",

pages = "171--177",

journal = "Hormone Research in Paediatrics",

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TY - JOUR

T1 - Effect of dihydroergocryptine and dihydroergocristine on cyclic amp accumulation and prolactin release in vitro

T2 - Evidence for a dopaminomimetic action

AU - Fiore, Lucia

AU - Scapagnini, Umberto

AU - Canonico, Pier Luigi

PY - 1987

Y1 - 1987

N2 - Dihydroergocryptine and dihydroergocristine, two C-9, 10-hydrogenated ergot alkaloids, inhibited in a concentration-dependent manner prolactin release and cyclic AMP accumulation in cultured anterior pituitary cells. The inhibitory effect of dihydroergocryptine was more potent and started at lower concentrations than that of dihydroergocristine. Haloperidol and pimozide, two dopamine receptor antagonists, completely abolished the inhibitory activity of the ergot alkaloids. The involvement of the adenylate cyclase-cyclic AMP system in the inhibitory action of the two compounds was demonstrated by the antagonism by pertussis toxin of the reduction of both prolactin release and cyclic AMP accumulation produced by dihydroergocryptine and dihydroergocristine.

AB - Dihydroergocryptine and dihydroergocristine, two C-9, 10-hydrogenated ergot alkaloids, inhibited in a concentration-dependent manner prolactin release and cyclic AMP accumulation in cultured anterior pituitary cells. The inhibitory effect of dihydroergocryptine was more potent and started at lower concentrations than that of dihydroergocristine. Haloperidol and pimozide, two dopamine receptor antagonists, completely abolished the inhibitory activity of the ergot alkaloids. The involvement of the adenylate cyclase-cyclic AMP system in the inhibitory action of the two compounds was demonstrated by the antagonism by pertussis toxin of the reduction of both prolactin release and cyclic AMP accumulation produced by dihydroergocryptine and dihydroergocristine.

KW - Cyclic AMP

KW - Dihydroergocristine

KW - Dihydroergocryptine

KW - Pertussis toxin

KW - Prolactin

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U2 - 10.1159/000180649

DO - 10.1159/000180649

M3 - Article

SN - 1663-2818

VL - 25

SP - 171

EP - 177

JO - Hormone Research in Paediatrics

JF - Hormone Research in Paediatrics

IS - 3

ER -

Effect of dihydroergocryptine and dihydroergocristine on cyclic amp accumulation and prolactin release in vitro: Evidence for a dopaminomimetic action

Abstract

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