Early diagnosis of invasive pulmonary aspergillosis in a young immunocompetent patient

Rosanna Vaschetto; Vesselina Kroumova; Carlo Olivieri; Valentina Bergamaschi; Laura Cancelliere; Silvio Borrè; Giacomo Fortina; Paolo Navalesi; Francesco Della Corte

Early diagnosis of invasive pulmonary aspergillosis in a young immunocompetent patient

Rosanna Vaschetto, Vesselina Kroumova, Carlo Olivieri, Valentina Bergamaschi, Laura Cancelliere, Silvio Borrè, Giacomo Fortina, Paolo Navalesi, Francesco Della Corte

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

A 22-year-old insulin-dependent diabetic male was admitted for diabetic ketoacidosis. He developed hospital-acquired pneumonia (HAP) for which empirical antibiotic and antifungal therapy was started on the ward. On day 6, clinical and laboratory findings worsened, and bronchoalveolar lavage (BAL) was performed. Serum real time-polymerase chain reaction (RT-PCR) indicated invasive pulmonary aspergillosis (IPA) and led to antifungal therapy being initiated 48 hours before the results of the BAL culture were available. Despite early appropriate antifungal therapy, however, the patient died on day 22 while being supported by venovenous extracorporeal membrane oxygenation.

Lingua originale	Inglese
pagine (da-a)	77-82
Numero di pagine	6
Rivista	New Microbiologica
Volume	35
Numero di pubblicazione	1
Stato di pubblicazione	Pubblicato - gen 2012

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title = "Early diagnosis of invasive pulmonary aspergillosis in a young immunocompetent patient",

abstract = "A 22-year-old insulin-dependent diabetic male was admitted for diabetic ketoacidosis. He developed hospital-acquired pneumonia (HAP) for which empirical antibiotic and antifungal therapy was started on the ward. On day 6, clinical and laboratory findings worsened, and bronchoalveolar lavage (BAL) was performed. Serum real time-polymerase chain reaction (RT-PCR) indicated invasive pulmonary aspergillosis (IPA) and led to antifungal therapy being initiated 48 hours before the results of the BAL culture were available. Despite early appropriate antifungal therapy, however, the patient died on day 22 while being supported by venovenous extracorporeal membrane oxygenation.",

keywords = "Diabetes, Invasive pulmonary aspergillosis, RT-PCR",

author = "Rosanna Vaschetto and Vesselina Kroumova and Carlo Olivieri and Valentina Bergamaschi and Laura Cancelliere and Silvio Borr{\`e} and Giacomo Fortina and Paolo Navalesi and {Della Corte}, Francesco",

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T1 - Early diagnosis of invasive pulmonary aspergillosis in a young immunocompetent patient

AU - Vaschetto, Rosanna

AU - Kroumova, Vesselina

AU - Olivieri, Carlo

AU - Bergamaschi, Valentina

AU - Cancelliere, Laura

AU - Borrè, Silvio

AU - Fortina, Giacomo

AU - Navalesi, Paolo

AU - Della Corte, Francesco

PY - 2012/1

Y1 - 2012/1

N2 - A 22-year-old insulin-dependent diabetic male was admitted for diabetic ketoacidosis. He developed hospital-acquired pneumonia (HAP) for which empirical antibiotic and antifungal therapy was started on the ward. On day 6, clinical and laboratory findings worsened, and bronchoalveolar lavage (BAL) was performed. Serum real time-polymerase chain reaction (RT-PCR) indicated invasive pulmonary aspergillosis (IPA) and led to antifungal therapy being initiated 48 hours before the results of the BAL culture were available. Despite early appropriate antifungal therapy, however, the patient died on day 22 while being supported by venovenous extracorporeal membrane oxygenation.

AB - A 22-year-old insulin-dependent diabetic male was admitted for diabetic ketoacidosis. He developed hospital-acquired pneumonia (HAP) for which empirical antibiotic and antifungal therapy was started on the ward. On day 6, clinical and laboratory findings worsened, and bronchoalveolar lavage (BAL) was performed. Serum real time-polymerase chain reaction (RT-PCR) indicated invasive pulmonary aspergillosis (IPA) and led to antifungal therapy being initiated 48 hours before the results of the BAL culture were available. Despite early appropriate antifungal therapy, however, the patient died on day 22 while being supported by venovenous extracorporeal membrane oxygenation.

KW - Diabetes

KW - Invasive pulmonary aspergillosis

KW - RT-PCR

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M3 - Article

SN - 1121-7138

VL - 35

SP - 77

EP - 82

JO - New Microbiologica

JF - New Microbiologica

IS - 1

ER -

Early diagnosis of invasive pulmonary aspergillosis in a young immunocompetent patient

Abstract

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