E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

D Galimberti; C Fenoglio; R Clerici; Cristoforo COMI; Riz M De; M Rottoli; L Piccio; M Ronzoni; E Venturelli; Francesco MONACO; M Poloni; N Bresolin; E. Scarpini

E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

D Galimberti, C Fenoglio, R Clerici, Cristoforo COMI, Riz M De, M Rottoli, L Piccio, M Ronzoni, E Venturelli, Francesco MONACO, M Poloni, N Bresolin, E. Scarpini

Dipartimento di Medicina Traslazionale

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

Lingua originale	Inglese
pagine (da-a)	201-205
Numero di pagine	5
Rivista	Journal of Neuroimmunology
Volume	165
Stato di pubblicazione	Pubblicato - 2005

Accesso al documento

http://hdl.handle.net/11579/29607

Altri file e collegamenti

handle

Cita questo

@article{81990e7333bd433fa0cd897078de78f2,

title = "E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis",

abstract = "Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.",

author = "D Galimberti and C Fenoglio and R Clerici and Cristoforo COMI and De, \{Riz M\} and M Rottoli and L Piccio and M Ronzoni and E Venturelli and Francesco MONACO and M Poloni and N Bresolin and E. Scarpini",

note = "Funding Information: This work was supported by grants from Associazione “Amici del Centro Dino Ferrari”, IRCCS Ospedale Maggiore Milano, Centre of Excellence for Neurodegenerative Diseases of the University of Milan and Ing. Cesare Cusan.",

year = "2005",

language = "English",

volume = "165",

pages = "201--205",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

AU - Galimberti, D

AU - Fenoglio, C

AU - Clerici, R

AU - COMI, Cristoforo

AU - De, Riz M

AU - Rottoli, M

AU - Piccio, L

AU - Ronzoni, M

AU - Venturelli, E

AU - MONACO, Francesco

AU - Poloni, M

AU - Bresolin, N

AU - Scarpini, E.

N1 - Funding Information: This work was supported by grants from Associazione “Amici del Centro Dino Ferrari”, IRCCS Ospedale Maggiore Milano, Centre of Excellence for Neurodegenerative Diseases of the University of Milan and Ing. Cesare Cusan.

PY - 2005

Y1 - 2005

N2 - Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

AB - Three hundred seven patients with MS and 300 controls were genotyped for G98T and A561C SNPs in the E-selectin gene, and genetic data were correlated with the course of the disease. The frequency of the T/T genotype of the G98T SNP was significantly increased in RR-MS patients compared with controls, while was absent in PP-MS. The frequency of the A561C SNP was significantly decreased in SP-MS compared with benign RR-MS. The T/T genotype of the G98T SNP is likely to confer an increased risk to develop MS. The A561C polymorphism seems to act as protective factor towards the progression to SP-MS.

UR - https://iris.uniupo.it/handle/11579/29607

M3 - Article

SN - 0165-5728

VL - 165

SP - 201

EP - 205

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

ER -

E-selectin A561C and G98T polymorphisms influence susceptibility and course of multiple sclerosis

Abstract

Accesso al documento

Altri file e collegamenti

Fingerprint

Cita questo