Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case

Gian Carlo Avanzi; Bruna Giovinazzo; Giuseppe Saglio; Angelo Guerrasio; Arturo Rosso; Marilena Bertini; Luigi Resegotti; Luigi Pegoraro

doi:10.1016/0165-4608(87)90030-6

Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case

Gian Carlo Avanzi, Bruna Giovinazzo, Giuseppe Saglio, Angelo Guerrasio, Arturo Rosso, Marilena Bertini, Luigi Resegotti, Luigi Pegoraro

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.

Lingua originale	Inglese
pagine (da-a)	57-63
Numero di pagine	7
Rivista	Cancer Genetics and Cytogenetics
Volume	29
Numero di pubblicazione	1
DOI	https://doi.org/10.1016/0165-4608(87)90030-6
Stato di pubblicazione	Pubblicato - nov 1987
Pubblicato esternamente	Sì

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title = "Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case",

abstract = "We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.",

author = "Avanzi, {Gian Carlo} and Bruna Giovinazzo and Giuseppe Saglio and Angelo Guerrasio and Arturo Rosso and Marilena Bertini and Luigi Resegotti and Luigi Pegoraro",

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AU - Avanzi, Gian Carlo

AU - Giovinazzo, Bruna

AU - Saglio, Giuseppe

AU - Guerrasio, Angelo

AU - Rosso, Arturo

AU - Bertini, Marilena

AU - Resegotti, Luigi

AU - Pegoraro, Luigi

PY - 1987/11

Y1 - 1987/11

N2 - We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.

AB - We describe the blastic transformation of a case of chronic myelocytic leukemia in which, among other abnormalities, one extra Philadelphia and one extra 9q+ were observed. Molecular studies and analysis of the clonal evolution of the karyotype led to the interpretation of such an unusual finding as the result of nondisjunction, rather than of a double t(9;22) translocation.

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U2 - 10.1016/0165-4608(87)90030-6

DO - 10.1016/0165-4608(87)90030-6

M3 - Article

SN - 0165-4608

VL - 29

SP - 57

EP - 63

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 1

ER -

Duplication of Ph and of 9q+ chromosomes during the blastic transformation of a CML case

Abstract

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