TY - JOUR
T1 - Downhill versus two-state protein folding in a statistical mechanical model
AU - Bruscolini, Pierpaolo
AU - Pelizzola, Alessandro
AU - Zamparo, Marco
PY - 2007
Y1 - 2007
N2 - The authors address the problem of downhill protein folding in the framework of a simple statistical mechanical model, which allows an exact solution for the equilibrium and a semianalytical treatment of the kinetics. Focusing on protein 1BBL, a candidate for downhill folding behavior, and comparing it to the WW domain of protein PIN1, a two-state folder of comparable size, the authors show that there are qualitative differences in both the equilibrium and kinetic properties of the two molecules. However, the barrierless scenario which would be expected if 1BBL were a true downhill folder is observed only at low enough temperature.
AB - The authors address the problem of downhill protein folding in the framework of a simple statistical mechanical model, which allows an exact solution for the equilibrium and a semianalytical treatment of the kinetics. Focusing on protein 1BBL, a candidate for downhill folding behavior, and comparing it to the WW domain of protein PIN1, a two-state folder of comparable size, the authors show that there are qualitative differences in both the equilibrium and kinetic properties of the two molecules. However, the barrierless scenario which would be expected if 1BBL were a true downhill folder is observed only at low enough temperature.
UR - http://www.scopus.com/inward/record.url?scp=34250012657&partnerID=8YFLogxK
U2 - 10.1063/1.2738473
DO - 10.1063/1.2738473
M3 - Article
SN - 0021-9606
VL - 126
JO - Journal of Chemical Physics
JF - Journal of Chemical Physics
IS - 21
M1 - 215103
ER -