Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation

Pierfrancesco Franco; Francesca Arcadipane; Riccardo Ragona; Adriana Lesca; Elena Gallio; Massimiliano Mistrangelo; Elisabetta Trino; Paola Cassoni; Vincenzo Arena; Massimo Baccega; Patrizia Racca; Riccardo Faletti; Nadia Rondi; Mario Morino; Umberto Ricardi

doi:10.1080/07357907.2018.1479413

Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation

Pierfrancesco Franco
, Francesca Arcadipane
, Riccardo Ragona
, Adriana Lesca
, Elena Gallio
, Massimiliano Mistrangelo
, Elisabetta Trino
, Paola Cassoni
, Vincenzo Arena
, Massimo Baccega
, Patrizia Racca
, Riccardo Faletti
, Nadia Rondi
, Mario Morino
, Umberto Ricardi

Risultato della ricerca: Contributo su rivista › Articolo in rivista › peer review

Abstract

Purpose: To investigate whether irradiated volume of pelvic active bone marrow (^ACTBM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation. Methods: Forty-four patients were analyzed and pelvic active bone marrow (^ACTBM) was characterized employing ¹⁸FDG-PET. Dosimetric parameters on dose–volume histograms were correlated to nadirs with generalized linear modeling. Results: ^ACTBM mean dose was significantly correlated to white blood cell (β = −1.338; 95%CI: −2.455/−0.221; p = 0.020), absolute neutrophil count (β = −1.651; 95%CI: −3.284/−0.183; p = 0.048), and platelets (β = −0.031; 95%CI: −0.057/−0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (^ACTBM-V_10,-V_20,-V₃₀and-V₄₀). Conclusions: ¹⁸FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.

Lingua originale	Inglese
pagine (da-a)	279-288
Numero di pagine	10
Rivista	Cancer Investigation
Volume	36
Numero di pubblicazione	5
DOI	https://doi.org/10.1080/07357907.2018.1479413
Stato di pubblicazione	Pubblicato - 28 mag 2018
Pubblicato esternamente	Sì

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10.1080/07357907.2018.1479413

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Franco, P., Arcadipane, F., Ragona, R., Lesca, A., Gallio, E., Mistrangelo, M., Trino, E., Cassoni, P., Arena, V., Baccega, M., Racca, P., Faletti, R., Rondi, N., Morino, M., & Ricardi, U. (2018). Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation. Cancer Investigation, 36(5), 279-288. https://doi.org/10.1080/07357907.2018.1479413

@article{0c3bd1d939d14fcea49e7031cdb17cb0,

title = "Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation",

abstract = "Purpose: To investigate whether irradiated volume of pelvic active bone marrow (ACTBM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation. Methods: Forty-four patients were analyzed and pelvic active bone marrow (ACTBM) was characterized employing 18FDG-PET. Dosimetric parameters on dose–volume histograms were correlated to nadirs with generalized linear modeling. Results: ACTBM mean dose was significantly correlated to white blood cell (β = −1.338; 95\%CI: −2.455/−0.221; p = 0.020), absolute neutrophil count (β = −1.651; 95\%CI: −3.284/−0.183; p = 0.048), and platelets (β = −0.031; 95\%CI: −0.057/−0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (ACTBM-V10,-V20,-V30and-V40). Conclusions: 18FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.",

keywords = "Anal cancer, Bone marrow, Concomitant radiochemotherapy, Hematologic toxicity, IMRT, PET, Radiotherapy",

author = "Pierfrancesco Franco and Francesca Arcadipane and Riccardo Ragona and Adriana Lesca and Elena Gallio and Massimiliano Mistrangelo and Elisabetta Trino and Paola Cassoni and Vincenzo Arena and Massimo Baccega and Patrizia Racca and Riccardo Faletti and Nadia Rondi and Mario Morino and Umberto Ricardi",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} Taylor \& Francis Group, LLC.",

year = "2018",

month = may,

day = "28",

doi = "10.1080/07357907.2018.1479413",

language = "English",

volume = "36",

pages = "279--288",

journal = "Cancer Investigation",

issn = "0735-7907",

publisher = "Taylor \& Francis Group LLC Philadelphia",

number = "5",

}

Franco, P, Arcadipane, F, Ragona, R, Lesca, A, Gallio, E, Mistrangelo, M, Trino, E, Cassoni, P, Arena, V, Baccega, M, Racca, P, Faletti, R, Rondi, N, Morino, M & Ricardi, U 2018, 'Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation', Cancer Investigation, vol. 36, n. 5, pagg. 279-288. https://doi.org/10.1080/07357907.2018.1479413

TY - JOUR

T1 - Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation

AU - Franco, Pierfrancesco

AU - Arcadipane, Francesca

AU - Ragona, Riccardo

AU - Lesca, Adriana

AU - Gallio, Elena

AU - Mistrangelo, Massimiliano

AU - Trino, Elisabetta

AU - Cassoni, Paola

AU - Arena, Vincenzo

AU - Baccega, Massimo

AU - Racca, Patrizia

AU - Faletti, Riccardo

AU - Rondi, Nadia

AU - Morino, Mario

AU - Ricardi, Umberto

PY - 2018/5/28

Y1 - 2018/5/28

N2 - Purpose: To investigate whether irradiated volume of pelvic active bone marrow (ACTBM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation. Methods: Forty-four patients were analyzed and pelvic active bone marrow (ACTBM) was characterized employing 18FDG-PET. Dosimetric parameters on dose–volume histograms were correlated to nadirs with generalized linear modeling. Results: ACTBM mean dose was significantly correlated to white blood cell (β = −1.338; 95%CI: −2.455/−0.221; p = 0.020), absolute neutrophil count (β = −1.651; 95%CI: −3.284/−0.183; p = 0.048), and platelets (β = −0.031; 95%CI: −0.057/−0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (ACTBM-V10,-V20,-V30and-V40). Conclusions: 18FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.

AB - Purpose: To investigate whether irradiated volume of pelvic active bone marrow (ACTBM) may predict decreased blood cells nadirs in anal cancer patients undergoing concurrent chemo-radiation. Methods: Forty-four patients were analyzed and pelvic active bone marrow (ACTBM) was characterized employing 18FDG-PET. Dosimetric parameters on dose–volume histograms were correlated to nadirs with generalized linear modeling. Results: ACTBM mean dose was significantly correlated to white blood cell (β = −1.338; 95%CI: −2.455/−0.221; p = 0.020), absolute neutrophil count (β = −1.651; 95%CI: −3.284/−0.183; p = 0.048), and platelets (β = −0.031; 95%CI: −0.057/−0.004; p = 0.024) nadirs. Other dosimetric parameters were found to be correlated (ACTBM-V10,-V20,-V30and-V40). Conclusions: 18FDG-PET is able to define active bone marrow and may predict for decreased blood cells count nadirs.

KW - Anal cancer

KW - Bone marrow

KW - Concomitant radiochemotherapy

KW - Hematologic toxicity

KW - IMRT

KW - PET

KW - Radiotherapy

UR - https://www.scopus.com/pages/publications/85049138544

U2 - 10.1080/07357907.2018.1479413

DO - 10.1080/07357907.2018.1479413

M3 - Article

SN - 0735-7907

VL - 36

SP - 279

EP - 288

JO - Cancer Investigation

JF - Cancer Investigation

IS - 5

ER -

Dose to Pelvic Bone Marrow Defined with FDG-PET Predicts for Hematologic Nadirs in Anal Cancer Patients Treated with Concurrent Chemo-radiation

Abstract

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