TY - JOUR
T1 - Dose-response study of GH effects on circulating IGF-I and IGFBP-3 levels in healthy young men and women
AU - Ghigo, E.
AU - Aimaretti, G.
AU - Maccario, M.
AU - Fanciulli, G.
AU - Arvat, E.
AU - Minuto, F.
AU - Giordano, G.
AU - Delitala, G.
AU - Camanni, F.
PY - 1999/6
Y1 - 1999/6
N2 - The aim of our study was to define the dose-response effect of a short- term treatment with different recombinant human growth hormone (rhGH) doses (1.25, 2.5, 5.0, 10.0, and 20.0 μg · kg-1 day-1 for 4 days) on insulin- like growth factor I (IGF-I) and insulin-like growth factor-binding protein (IGFBP)-3 levels in 21 normal young adults of both sexes. The dose of 1.25 μg/kg rhGH did not modify IGF-I levels. The dose of 2.5 μg/kg rhGH significantly increased IGF-I levels in men (P < 0.05) but not in women, whereas the higher doses increased IGF-I levels in both sexes (P < 0.002). IGFBP-3 levels were not modified by 1.25 or 2.5 μg/kg rhGH in either sex. On the other hand, 5.0 μg/kg increased IGFBP-3 levels in men (P < 0.05) but not in women, whereas the higher doses increased IGFBP-3 levels similarly in both sexes (P < 0.02). In conclusion, our results demonstrate that IGF-I and IGFBP-3 responses to rhGH are dose and sex dependent. However, IGFBP-3 is less sensitive than IGF-I to rhGH stimulation.
AB - The aim of our study was to define the dose-response effect of a short- term treatment with different recombinant human growth hormone (rhGH) doses (1.25, 2.5, 5.0, 10.0, and 20.0 μg · kg-1 day-1 for 4 days) on insulin- like growth factor I (IGF-I) and insulin-like growth factor-binding protein (IGFBP)-3 levels in 21 normal young adults of both sexes. The dose of 1.25 μg/kg rhGH did not modify IGF-I levels. The dose of 2.5 μg/kg rhGH significantly increased IGF-I levels in men (P < 0.05) but not in women, whereas the higher doses increased IGF-I levels in both sexes (P < 0.002). IGFBP-3 levels were not modified by 1.25 or 2.5 μg/kg rhGH in either sex. On the other hand, 5.0 μg/kg increased IGFBP-3 levels in men (P < 0.05) but not in women, whereas the higher doses increased IGFBP-3 levels similarly in both sexes (P < 0.02). In conclusion, our results demonstrate that IGF-I and IGFBP-3 responses to rhGH are dose and sex dependent. However, IGFBP-3 is less sensitive than IGF-I to rhGH stimulation.
KW - Insulin- like growth factor-binding protein-3
KW - Insulin-like growth factor I
KW - Insulin-like growth factor I generation test
KW - Recombinant human growth hormone
UR - https://www.scopus.com/pages/publications/0033002079
U2 - 10.1152/ajpendo.1999.276.6.e1009
DO - 10.1152/ajpendo.1999.276.6.e1009
M3 - Article
SN - 0193-1849
VL - 276
SP - E1009-E1013
JO - American Journal of Physiology - Endocrinology and Metabolism
JF - American Journal of Physiology - Endocrinology and Metabolism
IS - 6 39-6
ER -
