TY - JOUR
T1 - Does social cognition change? Evidence after 4 years from the Italian Network for Research on Psychoses
AU - Italian Network for Research on Psychoses
AU - Rocca, Paola
AU - Rucci, Paola
AU - Montemagni, Cristiana
AU - Rossi, Alessandro
AU - Bertolino, Alessandro
AU - Aguglia, Eugenio
AU - Altamura, Carlo A.
AU - Amore, Mario
AU - Andriola, Ileana
AU - Bellomo, Antonello
AU - Brasso, Claudio
AU - Carpiniello, Bernardo
AU - Del Favero, Elisa
AU - Dell'Osso, Liliana
AU - Di Fabio, Fabio
AU - Fabrazzo, Michele
AU - Fagiolini, Andrea
AU - Giordano, Giulia Maria
AU - Marchesi, Carlo
AU - Martinotti, Giovanni
AU - Monteleone, Palmiero
AU - Pompili, Maurizio
AU - Roncone, Rita
AU - Rossi, Rodolfo
AU - Siracusano, Alberto
AU - Tenconi, Elena
AU - Vita, Antonio
AU - Zeppegno, Patrizia
AU - Galderisi, Silvana
AU - Maj, Mario
AU - Bellino, Silvio
AU - Bozzatello, Paola
AU - Villari, Vincenzo
AU - Selvaggi, Pierluigi
AU - D'Ambrosio, Enrico
AU - Antonucci, Linda
AU - Barlati, Stefano
AU - Deste, Giacomo
AU - Nibbio, Gabriele
AU - Pinna, Federica
AU - Olivieri, Benedetta
AU - Manca, Daniela
AU - Concerto, Carmen
AU - FusarPoli, Laura
AU - Rodolico, Alessandro
AU - Pettorruso, Mauro
AU - D'Andrea, Giacomo
AU - Mosca, Alessio
AU - Altamura, Mario
AU - Gramaglia, Carla
N1 - Publisher Copyright:
© The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association.
PY - 2023/1/11
Y1 - 2023/1/11
N2 - Background Deficits in social cognition (SC) are significantly related to community functioning in schizophrenia (SZ). Few studies investigated longitudinal changes in SC and its impact on recovery. In the present study, we aimed: (a) to estimate the magnitude and clinical significance of SC change in outpatients with stable SZ who were assessed at baseline and after 4 years, (b) to identify predictors of reliable and clinically significant change (RCSC), and (c) to determine whether changes in SC over 4 years predicted patient recovery at follow-up. Methods The reliable change index was used to estimate the proportion of true change in SC, not attributable to measurement error. Stepwise multiple logistic regression models were used to identify the predictors of RCSC in a SC domain (The Awareness of Social Inference Test [TASIT]) and the effect of change in TASIT on recovery at follow-up. Results In 548 participants, statistically significant improvements were found for the simple and paradoxical sarcasm of TASIT scale, and for the total score of section 2. The reliable change index was 9.8. A cut-off of 45 identified patients showing clinically significant change. Reliable change was achieved by 12.6% and RCSC by 8% of participants. Lower baseline TASIT sect. 2 score predicted reliable improvement on TASIT sect. 2. Improvement in TASIT sect. 2 scores predicted functional recovery, with a 10-point change predicting 40% increase in the probability of recovery. Conclusions The RCSC index provides a conservative way to assess the improvement in the ability to grasp sarcasm in SZ, and is associated with recovery.
AB - Background Deficits in social cognition (SC) are significantly related to community functioning in schizophrenia (SZ). Few studies investigated longitudinal changes in SC and its impact on recovery. In the present study, we aimed: (a) to estimate the magnitude and clinical significance of SC change in outpatients with stable SZ who were assessed at baseline and after 4 years, (b) to identify predictors of reliable and clinically significant change (RCSC), and (c) to determine whether changes in SC over 4 years predicted patient recovery at follow-up. Methods The reliable change index was used to estimate the proportion of true change in SC, not attributable to measurement error. Stepwise multiple logistic regression models were used to identify the predictors of RCSC in a SC domain (The Awareness of Social Inference Test [TASIT]) and the effect of change in TASIT on recovery at follow-up. Results In 548 participants, statistically significant improvements were found for the simple and paradoxical sarcasm of TASIT scale, and for the total score of section 2. The reliable change index was 9.8. A cut-off of 45 identified patients showing clinically significant change. Reliable change was achieved by 12.6% and RCSC by 8% of participants. Lower baseline TASIT sect. 2 score predicted reliable improvement on TASIT sect. 2. Improvement in TASIT sect. 2 scores predicted functional recovery, with a 10-point change predicting 40% increase in the probability of recovery. Conclusions The RCSC index provides a conservative way to assess the improvement in the ability to grasp sarcasm in SZ, and is associated with recovery.
KW - Follow-up
KW - recovery
KW - reliable and clinically significant change (RCSC)
KW - schizophrenia
KW - social cognition
KW - theory of mind
UR - http://www.scopus.com/inward/record.url?scp=85147091530&partnerID=8YFLogxK
U2 - 10.1192/j.eurpsy.2022.2356
DO - 10.1192/j.eurpsy.2022.2356
M3 - Article
SN - 0924-9338
VL - 66
JO - European Psychiatry
JF - European Psychiatry
IS - 1
M1 - e10
ER -