Distribution of tumor necrosis factor alleles (NcoI RFLP) and their relationship to HLA haplotypes in an italian population

Daniela Peruccio, Sandra D’Alfonso, Iolanda Borelli, Antonio Amoroso, Gina Mazzola, Donato Marsico, Maura Bersanti, Patricia Richiardi

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The NcoI RFLP of the tumor necrosis factor (TNF) βgene was analyzed in a panel of 105 unrelated healthy Italian blood do-nors. The gene frequencies of the 10.5 kb and 5.5 kb allele were 0.73 and 0.27, respectively. The 5.5 kb band was significantly positively associated with HLA-A1, B8, DR 17.1, and C4AQ0, and negatively associated with DR7.2, DQw9 and C4A6, all being specificities which belong to two well-known Caucasoid ancestral haplotypes. When the population was subdivided on the basis of TNF phenotypes, different linkage disequilibria between HLA alleles were detected in the three phenotypic classes. From this analysis it was possible to relate preferential HLA associations, most of which are characteristic of ancestral haplotypes, to TNF polymorphism.

Lingua originaleInglese
pagine (da-a)103-110
Numero di pagine8
RivistaHuman Heredity
Volume43
Numero di pubblicazione2
DOI
Stato di pubblicazionePubblicato - 1993
Pubblicato esternamente

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