TY - JOUR
T1 - Distribution of Kaposi's sarcoma herpesvirus sequences among lymphoid malignancies in Italy and Spain
AU - Pastore, Cristina
AU - Gloghini, Annunziata
AU - Volpe, Gisella
AU - Nomdedeu, Josep
AU - Leonardo, Eugenio
AU - Mazza, Umberto
AU - Saglio, Giuseppe
AU - Carbonb, Antonino
AU - Gaidano, Gianluca
PY - 1995/12
Y1 - 1995/12
N2 - Summary. In this study we have tested the distribution of Kaposi's sarcoma herpesvirus (KSHV) DNA sequences throughout the spectrum of lymphoid neoplasia in Italy and Spain. 180 cases of lymphoid malignancies representative of the major histologic and immunophenotypic categories of B‐ and T‐cell tumours were analysed by means of a polymerase chain reaction‐based assay. KSHV sequences were consistently absent in all categories of lymphoid malignancies studied, with the exception of a subset of B‐cell non‐Hodgkin's lymphomas localizing in the pleural, pericardial or peritoneal cavities, and fulfilling the diagnostic criteria of body‐cavity‐based lymphoma. The selective and consistent association of KSHV sequences with cases of body‐cavity‐based lymphoma throughout the spectrum of lymphoid neoplasms suggests that KSHV may be involved in the pathogenesis of this peculiar type of lymphoid malignancy.
AB - Summary. In this study we have tested the distribution of Kaposi's sarcoma herpesvirus (KSHV) DNA sequences throughout the spectrum of lymphoid neoplasia in Italy and Spain. 180 cases of lymphoid malignancies representative of the major histologic and immunophenotypic categories of B‐ and T‐cell tumours were analysed by means of a polymerase chain reaction‐based assay. KSHV sequences were consistently absent in all categories of lymphoid malignancies studied, with the exception of a subset of B‐cell non‐Hodgkin's lymphomas localizing in the pleural, pericardial or peritoneal cavities, and fulfilling the diagnostic criteria of body‐cavity‐based lymphoma. The selective and consistent association of KSHV sequences with cases of body‐cavity‐based lymphoma throughout the spectrum of lymphoid neoplasms suggests that KSHV may be involved in the pathogenesis of this peculiar type of lymphoid malignancy.
KW - AIDS
KW - Kaposi's sarcoma herpesvirus
KW - acute lymphoblastic leukaemia
KW - body‐cavity‐based lymphoma
KW - non‐Hodgkin's lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0028853807&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.1995.tb05410.x
DO - 10.1111/j.1365-2141.1995.tb05410.x
M3 - Article
SN - 0007-1048
VL - 91
SP - 918
EP - 920
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 4
ER -
