Keyphrases
Mechanism of Action
100%
Colorectal Cancer
100%
Spiperone
100%
Drug Repurposing
100%
Endoplasmic Reticulum Ca2+
40%
Endoplasmic Reticulum Stress (ER stress)
40%
Apoptosis
20%
Lipid Metabolism
20%
Neoplastic Cells
20%
Intracellular Ca2+
20%
Ca2+ Homeostasis
20%
Phospholipase C
20%
Colorectal Cancer Cells
20%
Non-neoplastic
20%
Recurrent Disease
20%
Stem Cells
20%
Effective Compounds
20%
Developmental Period
20%
Ca2+ Release
20%
Metabolic Alterations
20%
Antitumor Activity
20%
Lipid Profile
20%
Metastatic Disease
20%
Drug pipeline
20%
Evidence Support
20%
Typical Antipsychotics
20%
RNA Sequencing (RNA-seq)
20%
Novel Therapeutics
20%
Apoptosis Induction
20%
Druggability
20%
Unfolded Protein Response
20%
Response Activation
20%
Antipsychotics
20%
Cell Cycle Arrest
20%
Golgi Apparatus
20%
Clinically Relevant Concentrations
20%
Colorectal Cancer Patients
20%
Drug Development
20%
Sphingolipids
20%
Inositol-requiring Enzyme 1 (IRE1)
20%
Lipid Analysis
20%
Development Cost
20%
Stress Induction
20%
Clonogenic Potential
20%
Medicine and Dentistry
Colorectal Carcinoma
100%
Drug Repositioning
100%
Spiperone
100%
Calcium Ion
42%
Programmed Cell Death
28%
Endoplasmic reticulum
28%
Endoplasmic Reticulum Stress
28%
Lipid Metabolism
14%
Homeostasis
14%
Metastatic Carcinoma
14%
Recurrent Disease
14%
Health Care Cost
14%
Cancer Cell
14%
Antineoplastic Activity
14%
Typical Antipsychotic
14%
Unfolded Protein Response
14%
Cell Cycle Arrest
14%
Golgi Apparatus
14%
Cell Cycle Checkpoint
14%
RNA Sequence
14%
Lipidomics
14%
Sphingolipid
14%
Messenger RNA
14%
Lecithinase
14%
Antipsychotic Drug
14%
Pharmacology, Toxicology and Pharmaceutical Science
Colorectal Carcinoma
100%
Spiperone
100%
Drug Repositioning
100%
Calcium Ion
42%
Drug Development
14%
Drug Discovery
14%
Recurrent Disease
14%
Antitumor Activity
14%
Typical Antipsychotic
14%
Sphingolipid
14%
RNA-Sequencing
14%
Messenger RNA
14%
Lecithinase
14%
Antipsychotic Drug
14%