TY - JOUR
T1 - Disease-specific and general health-related quality of life in newly diagnosed prostate cancer patients
T2 - The Pros-IT CNR study
AU - The Pros-IT CNR study group
AU - Porreca, Angelo
AU - Noale, Marianna
AU - Artibani, Walter
AU - Bassi, Pier Francesco
AU - Bertoni, Filippo
AU - Bracarda, Sergio
AU - Conti, Giario Natale
AU - Corvò, Renzo
AU - Gacci, Mauro
AU - Graziotti, Pierpaolo
AU - Magrini, Stefano Maria
AU - Mirone, Vincenzo
AU - Montironi, Rodolfo
AU - Muto, Giovanni
AU - Pecoraro, Stefano
AU - Ricardi, Umberto
AU - Russi, Elvio
AU - Tubaro, Andrea
AU - Zagonel, Vittorina
AU - Crepaldi, Gaetano
AU - Maggi, Stefania
AU - Alitto, Anna Rita
AU - Ambrosi, Enrica
AU - Antonelli, Alessandro
AU - Aristei, Cynthia
AU - Barbieri, Michele
AU - Bardari, Franco
AU - Bardoscia, Lilia
AU - Barra, Salvina
AU - Bartoncini, Sara
AU - Basso, Umberto
AU - Becherini, Carlotta
AU - Bellavita, Rita
AU - Bergamaschi, Franco
AU - Berlingheri, Stefania
AU - Berruti, Alfredo
AU - Borghesi, Marco
AU - Bortolus, Roberto
AU - Borzillo, Valentina
AU - Bosetti, Davide
AU - Bove, Giuseppe
AU - Bove, Pierluigi
AU - Maurizio, Brausi
AU - Alessio, Bruni
AU - Giorgio, Bruno
AU - Eugenio, Brunocilla
AU - Alberto, Buffoli
AU - Michela, Buglione
AU - Consuelo, Buttigliero
AU - Volpe, Alessandro
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/6/13
Y1 - 2018/6/13
N2 - Background: The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. Methods: One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). Results: At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. Conclusions: Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care.
AB - Background: The National Research Council (CNR) prostate cancer monitoring project in Italy (Pros-IT CNR) is an observational, prospective, ongoing, multicentre study aiming to monitor a sample of Italian males diagnosed as new cases of prostate cancer. The present study aims to present data on the quality of life at time prostate cancer is diagnosed. Methods: One thousand seven hundred five patients were enrolled. Quality of life is evaluated at the time cancer was diagnosed and at subsequent assessments via the Italian version of the University of California Los Angeles-Prostate Cancer Index (UCLA-PCI) and the Short Form Health Survey (SF-12). Results: At diagnosis, lower scores on the physical component of the SF-12 were associated to older ages, obesity and the presence of 3+ moderate/severe comorbidities. Lower scores on the mental component were associated to younger ages, the presence of 3+ moderate/severe comorbidities and a T-score higher than one. Urinary and bowel functions according to UCLA-PCI were generally good. Almost 5% of the sample reported using at least one safety pad daily to control urinary loss; less than 3% reported moderate/severe problems attributable to bowel functions, and sexual function was a moderate/severe problem for 26.7%. Diabetes, 3+ moderate/severe comorbidities, T2 or T3-T4 categories and a Gleason score of eight or more were significantly associated with lower sexual function scores at diagnosis. Conclusions: Data collected by the Pros-IT CNR study have clarified the baseline status of newly diagnosed prostate cancer patients. A comprehensive assessment of quality of life will allow to objectively evaluate outcomes of different profile of care.
KW - Diagnosis
KW - Pros-IT CNR study
KW - Prostate cancer
KW - Quality of life
UR - http://www.scopus.com/inward/record.url?scp=85048533399&partnerID=8YFLogxK
U2 - 10.1186/s12955-018-0952-5
DO - 10.1186/s12955-018-0952-5
M3 - Article
SN - 1477-7525
VL - 16
JO - Health and Quality of Life Outcomes
JF - Health and Quality of Life Outcomes
IS - 1
M1 - 122
ER -