Abstract
The Mycobacterium tuberculosis extracellular zinc metalloprotease 1 (Zmp1) has been proposed to play a key role in phagosome maturation and to enhance the survival of Mycobacterium tuberculosis in the host. Consequently, small molecule inhibitors of Zmp1 are of pivotal importance as a tool to better understand the pathogenicity of Zmp1 and as lead candidates for pharmacological intervention. Here we combined in silico structure-based inhibitor design with biochemical studies to discover and characterize the first potent competitive Zmp1 inhibitor showing a Ki of 94 nM and a high selectivity for Zmp1 with respect to human Neprilysin.
Lingua originale | Inglese |
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pagine (da-a) | 2508-2511 |
Numero di pagine | 4 |
Rivista | Bioorganic and Medicinal Chemistry Letters |
Volume | 24 |
Numero di pubblicazione | 11 |
DOI | |
Stato di pubblicazione | Pubblicato - 1 giu 2014 |