Keyphrases
Biological Assay
100%
Molecular Modeling Studies
100%
Trace Amine-associated Receptor 1 (TAAR1)
100%
Combination Strategy
100%
Guanfacine
100%
Adrenoceptors
25%
Template Molecule
12%
Receptor 2
12%
High Selectivity
12%
Computational Methods
12%
Positively Charged
12%
Charged Groups
12%
Structural Difference
12%
In Vitro Activity
12%
Monoaminergic
12%
Two-pathway
12%
Locomotor Activity
12%
G Protein-coupled Receptor
12%
Relationship Analysis
12%
Molecular Docking Studies
12%
Ligand Conformation
12%
Innovative Drugs
12%
Endogenous Ligand
12%
Activity Relationship
12%
Off-target Effects
12%
Low Selectivity
12%
Dual Activity
12%
Nanomolar Activity
12%
Dopamine Transporter Knockout Rats
12%
Selectivity Profile
12%
Structural Optimization
12%
Comparative Docking
12%
Biochemistry, Genetics and Molecular Biology
Agonist
100%
Molecular Model
100%
Trace Amine-Associated Receptor
100%
Guanfacine
100%
Conformation
12%
Monoaminergic
12%
Adrenergic Receptor
12%
G Protein Coupled Receptor
12%
Dopamine Transporter
12%
DNA Template
12%
Docking (Molecular)
12%
Knockout Rat
12%
Alpha-2 Adrenergic Receptor
12%
Pharmacology, Toxicology and Pharmaceutical Science
Receptor
100%
Guanfacine
100%
Adrenergic Receptor
11%
Lead Compound
11%
G Protein Coupled Receptor
11%
Alpha 2 Adrenergic Receptor
11%
Dopamine Transporter
11%
Knockout Rat
11%