Abstract
The effect of dihydroergocryptine, a natural alkaloid derivative which exhibits D2 dopaminomimetic properties, has been studied in Lewis female rats with experimentally induced allergic encephalomyelitis. A chronic treatment with dihydroergocryptine started two days before immunization, induced a dramatic reduction of prolactin levels accompanied by a marked amelioration of neurological signs. In addition, the proliferative activity of splenic lymphocytes induced by the mitogen Concanavalin-A (Con-A) was reduced in dihydroergocryptine-treated animals. It is suggested that this effect is related to the ability of dihydroergocryptine to lower prolactin concentrations or also, partially, to a neuroprotective action of this drug.
Lingua originale | Inglese |
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pagine (da-a) | 183-188 |
Numero di pagine | 6 |
Rivista | Functional Neurology |
Volume | 8 |
Numero di pubblicazione | 3 |
Stato di pubblicazione | Pubblicato - 1993 |
Pubblicato esternamente | Sì |