Dihydroergocryptine protects from acute experimental allergic encephalomyelitis in the rat

P. L. Canonico, M. A. Sortino, A. Favit, G. Aleppo, U. Scapagnini

Risultato della ricerca: Contributo su rivistaArticolo in rivistapeer review

Abstract

The effect of dihydroergocryptine, a natural alkaloid derivative which exhibits D2 dopaminomimetic properties, has been studied in Lewis female rats with experimentally induced allergic encephalomyelitis. A chronic treatment with dihydroergocryptine started two days before immunization, induced a dramatic reduction of prolactin levels accompanied by a marked amelioration of neurological signs. In addition, the proliferative activity of splenic lymphocytes induced by the mitogen Concanavalin-A (Con-A) was reduced in dihydroergocryptine-treated animals. It is suggested that this effect is related to the ability of dihydroergocryptine to lower prolactin concentrations or also, partially, to a neuroprotective action of this drug.

Lingua originaleInglese
pagine (da-a)183-188
Numero di pagine6
RivistaFunctional Neurology
Volume8
Numero di pubblicazione3
Stato di pubblicazionePubblicato - 1993
Pubblicato esternamente

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